A computational study of suppression of sharp wave ripple complexes by controlling calcium and gap junctions in pyramidal cells
| Autor: | Maxim Bazhenov, Abdul Aleem Awan, Kashif Zia, Hina Alam, Thomas Martinetz, Muhammad Mushtaq, Lars Hertel, Rizwan Haq, Lisa Marshall, Waqas Anwar |
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| Rok vydání: | 2021 |
| Předmět: |
hippocampus
Models Neurological Action Potentials chemistry.chemical_element Hippocampus Bioengineering Hippocampal formation Calcium Applied Microbiology and Biotechnology ca1 03 medical and health sciences 0302 clinical medicine Interneurons Postsynaptic potential Computer Simulation 030304 developmental biology 0303 health sciences Chemistry Pyramidal Cells Gap junction Gap Junctions Depolarization Sharp wave–ripple complexes Dendrites General Medicine sharp wave ripples Axons Synapses oscillations Biophysics Memory consolidation calcium influx TP248.13-248.65 030217 neurology & neurosurgery Research Article Research Paper Biotechnology |
| Zdroj: | Bioengineered, Vol 12, Iss 1, Pp 2603-2615 (2021) Bioengineered article-version (VoR) Version of Record |
| ISSN: | 2165-5987 2165-5979 |
| DOI: | 10.1080/21655979.2021.1936894 |
| Popis: | The hippocampus plays a key role in memory formation and learning. According to the concept of active systems memory consolidation, transiently stored memory traces are transferred from the hippocampus into the neocortex for permanent storage. This phenomenon relies on hippocampal network oscillations, particularly sharp wave ripples [SPW-Rs). In this process prior saved data in the hippocampus may be reactivated. Recent investigations reveal that several neurotransmitters and neuromodulators including norepinephrine, acetylcholine, serotonin, etc., suppress SPW-Rs activity in rodents’ hippocampal slices. This suppression of SPW-Rs may depend on various presynaptic and postsynaptic parameters including decrease in calcium influx, hyperpolarization/depolarization and alteration in gap junctions’ function in pyramidal cells. In this study, we demonstrate the impact of calcium influx and gap junctions on pyramidal cells for the modulation of SPW-Rs in a computational model of CA1. We used,SPW-Rs model with some modifications. SPW-Rs are simulated with gradual reduction of calcium and with decreasing conductance through gap junctions in PCs. Both, with calcium reduction as well as with conductance reduction through gap junctions, SPW-Rs are suppressed. Both effects add up synergistically in combination. Graphical abstract |
| Databáze: | OpenAIRE |
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