Monoamine oxidase A genotype, childhood adversity, and criminal behavior in an incarcerated sample
| Autor: | David Gangitano, Todd A. Armstrong, Shahida Flores, Mary Symonds, Brian B. Boutwell, Shawn Keller |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Genotype Young Adult Crime prevention Genetics medicine Humans Child Abuse Allele Young adult Psychiatry Large city Monoamine Oxidase Biological Psychiatry Genetics (clinical) Behavior biology Prisoners Criminals Middle Aged Criminal behavior Psychiatry and Mental health Variable number tandem repeat biology.protein Regression Analysis Self Report Monoamine oxidase A Psychology |
| Zdroj: | Psychiatric Genetics. 24:164-171 |
| ISSN: | 0955-8829 |
| DOI: | 10.1097/ypg.0000000000000033 |
| Popis: | Background A number of studies have found a functional variable number tandem repeat polymorphism in the upstream regulatory region of the monoamine oxidase A gene (MAOA-uVNTR) interacts with childhood adversity to increase risk for antisocial behavior. Several studies have also reported null findings. Methods Here, we examine the association between MAOA-uVNTR genotype, childhood adversity, and criminal activity in a sample of 99 male volunteers who were incarcerated in a large city jail in the Southern United States. MAOA-uVNTR genotypes were obtained from DNA extracted from buccal swabs. Criminal activity in the year before incarceration and childhood adversity were measured with self-report surveys. Violent arrest rates and property arrest rates were quantified with official records of arrest and accounted for periods of incarceration in local and state correctional facilities. Results The low expressing allele of the MAOA-uVNTR genotype (MAOAL) interacted with abuse to predict self-reports of less serious criminal and delinquent behavior and had a direct association with serious criminal activity. MAOAL genotype interacted with parental criminality to predict self-reports of serious criminal behavior, property arrest rates, and violent arrest rates. Conclusion The findings suggest that crime prevention efforts may be improved through attention to the neurodevelopmental consequence of gene-by-environment interactions. |
| Databáze: | OpenAIRE |
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