Repeated exposure to rewarding brain stimulation downregulates GluR1 expression in the ventral tegmental area
| Autor: | Andrea M. Pliakas, Mark S. Todtenkopf, William A. Carlezon, James R. Stellar, Monika Trzcinska, Patricia Pimentel, Donna L. McPhie |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Tyrosine 3-Monooxygenase Down-Regulation Stimulation Receptors N-Methyl-D-Aspartate Nicotine Rats Sprague-Dawley Reward Dopamine mental disorders medicine Animals Receptors AMPA Medial forebrain bundle Amphetamine Pharmacology musculoskeletal neural and ocular physiology Ventral Tegmental Area Brain Electric Stimulation Rats Ventral tegmental area Psychiatry and Mental health medicine.anatomical_structure nervous system Brain stimulation Brain stimulation reward Psychology Neuroscience psychological phenomena and processes medicine.drug |
| Zdroj: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 25(2) |
| ISSN: | 0893-133X |
| Popis: | There is considerable evidence that drug reward and brain stimulation reward (BSR) share common neural substrates. Although it is known that exposure to drugs of abuse causes a variety of molecular changes in brain reward systems, little is known about the molecular consequences of BSR. We report that repeated exposure to rewarding stimulation of the medial forebrain bundle (MFB) selectively decreases expression of GluR1 (an AMPA receptor subunit) in the VTA, without effect on expression of several other proteins (GluR2, NMDAR1, tyrosine hydroxylase). This effect of BSR on GluR1 expression is opposite of that caused by intermittent exposure to cocaine and morphine, which are known to elevate GluR1 expression in the VTA. Considering that elevated GluR1 expression in the VTA has been associated with increased sensitivity to drug reward, the finding that BSR and drugs of abuse have opposite effects on GluR1 expression in this region may provide an explanation for why the reward-related effects of many drugs (cocaine, morphine, amphetamine, PCP, nicotine) do not sensitize with repeated testing in BSR procedures that quantify reward strength. |
| Databáze: | OpenAIRE |
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