Hepatoprotective and antioxidant effects of lycopene in acute cholestasis
| Autor: | Ayşe Nurşen Başaran, Sevtap Aydin, Mine Yavuz Taşlipinar, A. Ahmet Başaran, Mehmet Doğan, Mehmet Kılıç, Alper Bilal Özkardeş, Gökçe Taner, Halit Ziya Dündar, Mehmet Tokaç |
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| Přispěvatelé: | Farmasötik Toksikoloji |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Antioxidant medicine.medical_treatment medicine.disease_cause Nitric Oxide digestive system Antioxidants Superoxide dismutase chemistry.chemical_compound Lycopene Cholestasis Liver Function Tests General & Internal Medicine Internal medicine Malondialdehyde medicine Animals Lymphocytes Rats Wistar biology business.industry Superoxide Dismutase General Medicine Glutathione Lycopene cholestasis DNA damage oxidative stress peripheral lymphocytes liver medicine.disease Catalase Carotenoids digestive system diseases Rats Disease Models Animal Oxidative Stress Endocrinology chemistry Cytoprotection biology.protein Hepatocytes Liver function business Oxidative stress DNA Damage |
| Zdroj: | Volume: 45, Issue: 4 857-864 Turkish Journal of Medical Sciences |
| ISSN: | 1300-0144 1303-6165 |
| Popis: | Background/aim: Lycopene, which is suggested to be a potent antioxidant, may play a protective role in diseases related to oxidative stress. In order to understand the effects of lycopene in the pathogenesis of cholestasis, we investigated the effects of lycopene on oxidative stress parameters and DNA damage induced by experimental biliary obstruction in the liver tissues and the lymphocytes of Wistar albino rats. Materials and methods: The animals were randomized into 3 groups. The sham group was subjected to a sham operation, the BDL group was subjected to bile duct ligation (BDL), and the BDL+L group was subjected to BDL and treated with 10 mg/kg body weight of lycopene. After 7 days of treatment, the liver functions, oxidative stress parameters, and DNA damage were evaluated. Results: The lycopene treatment significantly ameliorated the liver function parameters in BDL rats. It significantly reduced malondialdehyde and nitric oxide levels and enhanced reduced glutathione levels and catalase, superoxide dismutase, and glutathione S transferase activities in the BDL rats. The lycopene treatment also decreased DNA damage as assessed by comet assay in the lymphocytes and hepatocytes of the BDL rats. Conclusion: These results suggest that lycopene might have protective effects on acute cholestasis. |
| Databáze: | OpenAIRE |
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