Frequency-Dependent Interictal Neuromagnetic Activities in Children With Benign Epilepsy With Centrotemporal Spikes: A Magnetoencephalography (MEG) Study
| Autor: | Zheng Hu, Jintao Sun, Yuan Gao, Tingting Zhang, Caiyun Wu, Qiqi Chen, Qi Shi, Hu Guo, Ailiang Miao, Yihan Li, Xiaoshan Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
magnetoencephalography
medicine.medical_specialty interictal epileptiform discharges Brain activity and meditation Precuneus Audiology 050105 experimental psychology lcsh:RC321-571 Temporal lobe 03 medical and health sciences Behavioral Neuroscience Epilepsy magnetic source imaging 0302 clinical medicine medicine 0501 psychology and cognitive sciences Ictal lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Default mode network Original Research medicine.diagnostic_test business.industry 05 social sciences Human Neuroscience Magnetoencephalography medicine.disease Psychiatry and Mental health Neuropsychology and Physiological Psychology medicine.anatomical_structure Neurology Posterior cingulate benign epilepsy with centrotemporal spikes low- to high-frequency bands business 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Human Neuroscience, Vol 14 (2020) Frontiers in Human Neuroscience |
| ISSN: | 1662-5161 |
| Popis: | Objective: This study aimed to investigate interictal neuromagnetic activities in the low- to high-frequency ranges in patients with benign epilepsy with centrotemporal spikes (BECTS), especially those without interictal epileptiform discharges (IEDs). Methods: We studied 21 clinically-diagnosed BECTS patients and 11 age-matched healthy controls (HC) using high-sampling magnetoencephalography (MEG). Neuromagnetic sources were assessed with accumulated source imaging (ASI). The MEG data were analyzed in seven frequency bands. The MEG recordings distinguished BECTS without IEDs (n = 10) from those with IEDs (n = 11) and HC (n = 11). Results: At 1–4 Hz, the neuromagnetic activities in healthy subjects tended to locate at the precuneus/posterior cingulate, while those of the BECTS patients without IEDs tended to locate at the medial frontal cortex (MFC) compared to BECTS patients with IEDs. The MEG source imaging at 30–80 Hz revealed that BECTS patients without IEDs had higher occurrences of interictal brain activity in the medial temporal lobe (MTL) compared to controls and the brain activity strength seemed to be weaker. There was a significant correlation between the source strength of the interictal gamma oscillations of BECTS patients without IEDs and the duration of epilepsy. Conclusions: IEDs might disrupt the default mode network (DMN). Aberrant brain activities in BECTS patients without IEDs were associated with cognitive areas of the brain. The strength of gamma oscillations in the chronic epilepsy state reflected the duration of BECTS. Significance: MEG could reveal the aberrant neural activities in BECTS patients during the interictal period, and such abnormality is frequency-dependent. Gamma oscillations could be used to identify BECTS patients without IEDs. |
| Databáze: | OpenAIRE |
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