The cost-effectiveness of HPV vaccination in addition to screening

Autor: Maarten J. Postma, Tjalke A Westra, Bob Wilffert, Jos Luttjeboer, Toos Daemen, Auliya A. Suwantika, Jan Wilschut, Didik Setiawan, Jarir Atthobari
Přispěvatelé: Microbes in Health and Disease (MHD), Targeted Gynaecologic Oncology (TARGON), Methods in Medicines evaluation & Outcomes research (M2O), Reproductive Origins of Adult Health and Disease (ROAHD), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Value, Affordability and Sustainability (VALUE)
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Expert review of vaccines, 14(4), 589-604. TAYLOR & FRANCIS LTD
ISSN: 1744-8395
1476-0584
Popis: Addition of the HPV vaccine to available cytological screening has been proposed to increase HPV-related cancer prevention. A comprehensive review on this combined strategy implemented in the Netherlands is lacking. For this review, we therefore analyzed all relevant studies on cost-effectiveness of HPV vaccines in combination with cervical screening in the Netherlands. Most of the studies agree that vaccination in pre-sexual-activity periods of life is cost-effective. Based on published sensitivity analyses, the incremental cost-effectiveness ratio was found to be mainly driven by vaccine cost and discount rates. Fewer vaccine doses, inclusion of additional benefits of these vaccines to prevent HPV-related non-cervical cancers and vaccination of males to further reduce the burden of HPV-induced cancers are three relevant options suggested to be investigated in upcoming economic evaluations.
Databáze: OpenAIRE