Neointimal fibrotic lead encapsulation – Clinical challenges and demands for implantable cardiac electronic devices
| Autor: | Jonas Keiler, Andreas Wree, Tina Tischer, M Schulze, Thomas Heller, Dietmar Bänsch, Martina Sombetzki, Niels Grabow |
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| Rok vydání: | 2017 |
| Předmět: |
Pacemaker
Artificial medicine.medical_specialty Vascular fibrosis business.industry medicine.medical_treatment 030204 cardiovascular system & hematology Fibrosis Cardiac pacemaker Defibrillators Implantable Encapsulation (networking) 03 medical and health sciences 0302 clinical medicine Neointima Internal medicine medicine Cardiology Lead failure Humans 030212 general & internal medicine Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiology. 70:7-17 |
| ISSN: | 0914-5087 |
| DOI: | 10.1016/j.jjcc.2017.01.011 |
| Popis: | Every tenth patient with a cardiac pacemaker or implantable cardioverter-defibrillator implanted is expected to have at least one lead problem in his lifetime. However, transvenous leads are often difficult to remove due to thrombotic obstruction or extensive neointimal fibrotic ingrowth. Despite its clinical significance, knowledge on lead-induced vascular fibrosis and neointimal lead encapsulation is sparse. Although leadless pacemakers are already available, their clinical operating range is limited. Therefore, lead/tissue interactions must be further improved in order to improve lead removals in particular. The published data on the coherences and issues related to lead associated vascular fibrosis and neointimal lead encapsulation are reviewed and discussed in this paper. |
| Databáze: | OpenAIRE |
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