Enhancement of collagen-induced aggregation of platelets in whole blood
| Autor: | Funahara Y, Rahajuningsih Setiabudy-Dharma |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
Erythrocytes Time Factors Epinephrine Platelet Aggregation Platelet aggregation Cell Count medicine Humans Platelet Whole blood Human blood Dilazep Chemistry Temperature Hematology Blood Physiological Phenomena Adenosine Diphosphate Erythrocyte membrane Biochemistry Platelet-rich plasma Biophysics Female Collagen medicine.drug |
| Zdroj: | Thrombosis Research. 42:621-634 |
| ISSN: | 0049-3848 |
| DOI: | 10.1016/0049-3848(86)90341-5 |
| Popis: | In order to elucidate the features of platelet aggregation in whole blood, studies were carried out on human blood. The platelet aggregation reaction was monitored by counting the residual free platelet number with an electronic particle counter (Coulter). Platelets in citrated whole blood were aggregated by a very small amount of collagen which did not aggregate platelets in citrated plasma. Such enhancement was not observed if ADP or epinephrine was used. By addition of isolated erythrocytes to platelet rich plasma, enhancement of the platelet response to collagen was obtained. The erythrocyte membrane stabilizer, Dilazep, abolished the enhancement effect of erythrocytes. Those results indicated that erythrocytes enhanced the platelet response to collagen. Although participation of ADP from the erythrocytes in the enhancement was suggested, the results of ADP determinations on suspensions of erythrocytes indicated that other factors of the erythrocytes might be involved in the enhancement. |
| Databáze: | OpenAIRE |
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