Expression of platelet-derived growth factor ligand and receptor in cerebral arteriovenous and cavernous malformations
| Autor: | Ozlem Kurtkaya, Atilla Biçer, Ozlem Yildirim, Beyazid Cirakoglu, Abdulkadir Ozkan, Turker Kilic |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Intracranial Arteriovenous Malformations
Hemangioma Cavernous Central Nervous System Pathology medicine.medical_specialty Platelet-derived growth factor Angiogenesis medicine.medical_treatment Blotting Western Ligands Central Nervous System Neoplasms chemistry.chemical_compound Physiology (medical) Adventitia medicine Humans Receptors Platelet-Derived Growth Factor Receptor Platelet-Derived Growth Factor biology business.industry Growth factor Proto-Oncogene Proteins c-sis General Medicine Cavernous malformations medicine.disease Immunohistochemistry Vascular endothelial growth factor medicine.anatomical_structure Neurology chemistry cardiovascular system biology.protein Surgery Neurology (clinical) business Platelet-derived growth factor receptor |
| Zdroj: | Journal of Clinical Neuroscience. 17:1557-1562 |
| ISSN: | 0967-5868 |
| DOI: | 10.1016/j.jocn.2010.04.028 |
| Popis: | The aim of this study was to investigate the expression of platelet-derived growth factor (PDGF) ligands A and B and receptors α and β in cerebral arteriovenous and cavernous malformations. Fifteen arteriovenous malformation (AVM) and 15 cerebral cavernous malformation (CCM) tissue samples were immunostained for PDGF ligands A and B, PDGF receptors (PDGFR) α and β, and vascular endothelial growth factor. Tissues were compared in terms of expression levels within various vascular layers, and the results were confirmed using western blotting. AVM had higher levels of PDGF-A expression than CCM (p = 0.004, 0.009, 0.001, and 0.027, for endothelium, media, adventitia, and perilesional tissue, respectively) and western blotting showed that there was higher expression of PDGFR-α in AVM tissues. In contrast, CCM endothelium, media, and adventitia had higher PDGF-B expression compared with AVM (p = 0.007, 0.001, and 0.039, respectively). PDGFR-β expression was also significantly higher in the endothelium of CCM tissue (p = 0.007). Overexpression of PDGF ligands and receptors in AVM and CCM may mean that therapeutic strategies targeting the PDGF pathway could be useful in the treatment of these two malformations. |
| Databáze: | OpenAIRE |
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