Diverse progenitor cells preserve salivary gland ductal architecture after radiation induced damage
| Autor: | Ophir D. Klein, Noel Cruz-Pacheco, Alison J May, Sara Nathan, Marcus O. Muench, Elaine Emmerson, Kerstin Seidel, Sarah M. Knox |
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| Rok vydání: | 2018 |
| Předmět: |
0303 health sciences
Salivary gland Ductal cells Cellular differentiation Cell Biology Cell biology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis medicine Salivary Ducts Progenitor cell Homeostasis 030304 developmental biology Progenitor |
| Popis: | The ductal system of the salivary gland has long been postulated to be resistant to radiation-induced damage, a common outcome incurred by head and neck cancer patients receiving radiotherapy. Yet, whether the ducts are capable of regenerating after genotoxic injury, or if damage to ductal cells induces lineage plasticity, as has been reported in other organ systems, remains unknown. Here, we show that two ductal progenitor populations marked by KRT14 and KIT exclusively maintain non-overlapping ductal compartments after radiation exposure but do so through distinct cellular mechanisms. KRT14+ progenitor cells are fast cycling cells that proliferate in response to radiation-induced damage in a sustained manner and divide asymmetrically to produce differentiated cells of the larger granulated ducts. Conversely, KIT+ cells are long lived progenitors for the intercalated ducts that undergo few cell divisions either during homeostasis or after gamma radiation, thus maintaining ductal architecture in the near absence of cell turnover. Together, these data illustrate the regenerative capacity of the salivary ducts and highlight the heterogeneity in the damage responses used by salivary progenitor cells to maintain tissue architecture.Summary StatementThe salivary gland ductal network is maintained during homeostasis and after genotoxic injury by diverse progenitors that respond differentially to radiation induced damage. |
| Databáze: | OpenAIRE |
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