The effect of melatonin and/or complex vitamin B1,B6,B12 in modulating epinephrine-induced stress in male rats
| Autor: | Nema A. Mohamed, Wessam Mohamed Abdel-Wahab, Mona Y. El-Toweissy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Vitamin
medicine.medical_specialty Multidisciplinary medicine.diagnostic_test Glycogen Epinephrine Insulin medicine.medical_treatment lcsh:Biotechnology Blood sugar Malondialdehyde Stress Rats Melatonin chemistry.chemical_compound Endocrinology chemistry Tri-B Internal medicine lcsh:TP248.13-248.65 medicine Lipid profile medicine.drug |
| Zdroj: | Brazilian Archives of Biology and Technology, Vol 56, Iss 3, Pp 393-403 (2013) Brazilian Archives of Biology and Technology, Volume: 56, Issue: 3, Pages: 393-403, Published: JUN 2013 Brazilian Archives of Biology and Technology v.56 n.3 2013 Brazilian Archives of Biology and Technology Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
| ISSN: | 1678-4324 |
| Popis: | This study was undertaken to determine the modulating effects of intramuscular administration of melatonin (MT)(1mg/ kg) and/or Tri-B (B 1 , B 6 and B 12 ) (20mg/kg) on body weight and some biochemical changes in rats induced by Epinephrine (Epi) injection. The data showed that MT and/or Tri-B treatment effectively improved the changes in malondialdehyde, lipid profile, blood sugar level and insulin. MT and/or Tri-B administration following Epi improved partially the decrease in body weight and liver glycogen levels. Tri B injection following Epi partialy improved all the tested parameters except malondialdehyde and blood sugar level that completely improved in stressed rats. It was evident that a combination of MT and vitamin B complex had protective actions and further it was better than either of them introduced alone in stressed rats. The possible interaction between MT and Tri B provided further support to MT synergistic actions with the aim of advocating MT and Tri B as a possible synergistic therapy. |
| Databáze: | OpenAIRE |
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