To measure or not to measure direct oral anticoagulants before surgery or invasive procedures: comment
| Autor: | L. Black, S. Kulkarni, Robert R. Selby, Z. Shah, J. Ongteco, D. Piraino |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.drug_mechanism_of_action business.industry Factor Xa Inhibitor Administration Oral Anticoagulants Hematology 030204 cardiovascular system & hematology Anticoagulant activity Dabigatran Surgery 03 medical and health sciences 0302 clinical medicine medicine Humans 030212 general & internal medicine business Coagulation analyzers circulatory and respiratory physiology medicine.drug Factor Xa Inhibitors |
| Zdroj: | Journal of thrombosis and haemostasis : JTH. 15(1) |
| ISSN: | 1538-7836 |
| Popis: | With interest, we read a recent publication by Armando Tripodi, aimed at discussing whether direct oral anticoagulants (DOACs) should be measured prior to surgical or invasive procedures [1]. Although specific assays for the assessment of anticoagulant activity of the direct oral anticoagulants (dabigatran and the oral factor Xa inhibitors) have been developed and are easy to perform on automated coagulation analyzers [1-3], they are currently not available in the majority of Ontario laboratories. Since the APTT is readily available at most of our laboratories, we studied the effect of different dabigatran concentrations on the APTT, using six different APTT reagents and performed on three coagulation analyzer platforms. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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