Abnormal pattern of left atrial activation and asynchronous conduction predicted the occurrence of new atrial fibrillation: evidences for Bachmann's bundle block in atrial fibrillation pathophysiology
| Autor: | Andreas Bollmann, Gerhard Hindricks, Kaloyan Marinov, Sotirios Nedios, Borislav Dinov, Timm Seewöster, Helge Knopp, Susanne Löbe |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Doppler imaging Activation pattern Left atrial Physiology (medical) Internal medicine Atrial Fibrillation medicine Humans Atrial Appendage Bachmann's bundle Heart Atria Prospective Studies Prospective cohort study Coronary sinus Aged business.industry Atrial fibrillation Atrial Remodeling Middle Aged medicine.disease Pathophysiology medicine.anatomical_structure Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 23(8) |
| ISSN: | 1532-2092 |
| Popis: | Aims Evidences suggest that recurrent atrial fibrillation (AF) is associated with left atrial (LA) remodelling. The goal of this study is to establish a method for assessment of LA remodelling and find predictors for the development of AF. Methods and results This prospective study included patients without a history of AF who were evaluated using pulsed-wave tissue Doppler imaging (PW-TDI). P-wave onset to A′-wave (PA′ interval) was measured at the septal, lateral, anterior, and inferior mitral annulus. Abnormal LA activation pattern was defined as an upward LA activation over the coronary sinus and delayed activation anterior. Left atrial asynchrony was measured as (i) the difference between the septal and lateral PA′ interval (DLS) and (ii) the standard deviation of all four PA′ intervals (SD4-PA′). The follow-up for AF recurrence (AF+) was based on symptoms and 7-day Holter electrocardiograms. Ninety-eight patients (mean age 58 ± 15 years, 47% female) were included. During a follow-up of 28 ± 9 months, AF was documented in 10%. More pronounced LA asynchrony was observed in AF+ group: DLS (AF+) 39 ± 16 vs. DLS (AF−) 20 ± 11 ms; P Conclusions More pronounced LA asynchrony and abnormal LA activation pattern were associated with new-onset AF. |
| Databáze: | OpenAIRE |
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