The impact of MRI sequence on tumour staging and gross tumour volume delineation in squamous cell carcinoma of the anal canal
| Autor: | Rob Glynne-Jones, Davide Prezzi, Andrew Gaya, Ramin Mandegaran, Vicky Goh, K. Owczarczyk, Sofia Gourtsoyianni |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Gastrointestinal medicine.medical_specialty Diffusion magnetic resonance imaging Intraclass correlation Anal Canal Radiotherapy image-guided 030218 nuclear medicine & medical imaging 03 medical and health sciences Magnetic resonance imaging 0302 clinical medicine medicine Humans Anal cancer Radiology Nuclear Medicine and imaging Basal cell Anus neoplasms cardiovascular diseases Aged Retrospective Studies Neuroradiology Aged 80 and over medicine.diagnostic_test business.industry Ultrasound General Medicine Middle Aged Anal canal Anus Neoplasms medicine.disease Tumor Burden medicine.anatomical_structure ROC Curve 030220 oncology & carcinogenesis Neoplasm staging Carcinoma Squamous Cell T-stage Female Radiology business |
| Zdroj: | European Radiology Prezzi, D, Mandegaran, R, Gourtsoyianni, S, Owczarczyk, K, Gaya, A, Glynne-Jones, R & Goh, V 2017, ' The impact of MRI sequence on tumour staging and gross tumour volume delineation in squamous cell carcinoma of the anal canal ', European Radiology, pp. 1-8 . https://doi.org/10.1007/s00330-017-5133-0 |
| ISSN: | 1432-1084 0938-7994 |
| DOI: | 10.1007/s00330-017-5133-0 |
| Popis: | Objectives: To compare maximum tumour diameter (MTD) and gross tumour volume (GTV) measurements between T2-weighted (T2-w) and diffusion-weighted (DWI) MRI in squamous cell carcinoma of the anal canal (SCCA) and assess sequence impact on tumour (T) staging. Second, to evaluate interobserver agreement and reader delineation confidence. Methods: The staging MRI scans of 45 SCCA patients (25 females) were assessed retrospectively by two independent radiologists (0 and 5 years’ experience of anal cancer MRI). MTD and GTV were delineated on both T2-w and high-b-value DWI images and compared between sequences; T staging was derived from MTD. Interobserver agreement was assessed and delineation confidence scored (1 to 5) by each observer. Results: GTV and MTD were significantly and systematically lower on DWI versus T2-w sequences by 14.80%/9.98% (MTD) and 29.70%/12.25% (GTV) for each reader, respectively, causing T staging discordances in approximately a quarter of cases. Bland-Altman limits of agreement were narrower and intraclass correlation coefficients higher for DWI. Delineation confidence was greater on DWI: 40/42 cases were scored confidently (4 or 5) by each reader, respectively, versus 31/36 cases based on T2-w images. Conclusions: Sequence selection affects SCCA measurements and T stage. DWI yields higher interobserver agreement and greater tumour delineation confidence. Key Points: • MTD and GTV measurements are significantly lower on DWI than on T2-w MRI. • Such differences cause T staging discordances in up to a quarter of cases. • DWI results in higher agreement between inexperienced and experienced observers. • DWI offers greater tumour delineation confidence to inexperienced readers. |
| Databáze: | OpenAIRE |
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