Dexamethasone inhibits virus production and the secretory IgA response in oesophageal–pharyngeal fluid in cattle persistently infected with foot-and-mouth disease virus
| Autor: | R. P. Kitching, J. S. Salt, Rosalind M. Gaskell, M. C. Ilott |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Immunoglobulin A
medicine.medical_specialty Epidemiology medicine.drug_class Anti-Inflammatory Agents Cattle Diseases Disease Vectors Virus Replication Dexamethasone Virus Aphthovirus Esophagus Immune system Internal medicine medicine Animals biology biology.organism_classification Neutrophilia Infectious Diseases Endocrinology Foot-and-Mouth Disease Immunoglobulin A Secretory Immunology biology.protein Pharynx Corticosteroid Cattle Foot-and-mouth disease virus medicine.symptom Research Article medicine.drug |
| Zdroj: | Epidemiology and Infection. 118:181-187 |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268896007376 |
| Popis: | Cattle persistently infected with foot-and-mouth disease virus were treated with dexamethasone to suppress the immune system in an attempt to influence the level of virus recovery from oesophageal–pharyngeal (probang) samples. Twelve carrier cattle were assigned to one of three groups: control; 0·1 mg/kg dexamethasone; and 0·5 mg/kg dexamethasone. Groups 2 and 3 were injected intramuscularly three times weekly for 3 weeks with dexamethasone between days 33 and 56 post-infection with foot-and-mouth disease virus (FMDV). Cattle in both groups developed a leucocytosis, neutrophilia and lymphopenia. The secretory IgA response to FMDV infection was inhibited following, but not during, dexamethasone treatment between days 70 and 98 post-infection (PP |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|