Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis
| Autor: | Eric Epping, Peggy Nopoulos, Anne Rosser, Nellie Georgiou-Karistianis, Stefan Klöppel, Roger Alistair Barker, Stacie Vik, Yongxia (Sharon) Zhou, Mirza Faisal Beg, Douglas Langbehn, Thomas Warner, Julie Stout, David Moser, Lynn Raymond, Ergun Uc, Anita Goh, Phyllis Chua, Hans Johnson, Kylie Radford, Thomas Wassink, Alexandra Margaret Ure, Charlotte Soneson, William Coryell, Carmela Pestell, WR Wayne Martin, Michael Hayden, Georg Bernhard Landwehrmeyer, Jane Paulsen, Vincent Magnotta |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Heterozygote Pathology medicine.medical_specialty Huntingtin Hypothalamus Disease Grey matter computer.software_genre Article Imaging lcsh:RC321-571 Atrophy Voxel Basal ganglia medicine Humans Longitudinal Studies lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry medicine.diagnostic_test Magnetic resonance imaging Voxel-based morphometry medicine.disease Magnetic Resonance Imaging Neuroendocrine Early Diagnosis Huntington Disease medicine.anatomical_structure Neurology Female Psychology computer |
| Zdroj: | Neurobiology of Disease, Vol 40, Iss 3, Pp 531-543 (2010) |
| ISSN: | 0969-9961 |
| DOI: | 10.1016/j.nbd.2010.07.013 |
| Popis: | Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat. Its length can be used to estimate the time of clinical diagnosis, which is defined by overt motor symptoms. Non-motor symptoms begin before motor onset, and involve changes in hypothalamus-regulated functions such as sleep, emotion and metabolism. Therefore we hypothesized that hypothalamic changes occur already prior to the clinical diagnosis. We performed voxel-based morphometry and logistic regression analyses of cross-sectional MR images from 220 HD gene carriers and 75 controls in the Predict-HD study. We show that changes in the hypothalamic region are detectable before clinical diagnosis and that its grey matter contents alone are sufficient to distinguish HD gene carriers from control cases. In conclusion, our study shows, for the first time, that alterations in grey matter contents in the hypothalamic region occur at least a decade before clinical diagnosis in HD using MRI. |
| Databáze: | OpenAIRE |
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