X-ray Structure of Citrate Bound to Src SH2 Leads to a High-Affinity, Bone-Targeted Src SH2 Inhibitor
| Autor: | Regine S. Bohacek, Karina J. Macek, Manfred Weigele, Marcos Hatada, Tomi K. Sawyer, William C. Shakespeare, Chester A. Metcalf, David C. Dalgarno, Berkley A. Lynch, Surinder S. Narula, Taylor Merry, Shelia Violette, Virginia A. Jacobsen |
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| Rok vydání: | 2001 |
| Předmět: |
Models
Molecular Molecular model Stereochemistry Proto-Oncogene Proteins pp60(c-src) Osteoclasts Crystallography X-Ray Ligands SH2 domain Chemical synthesis Bone and Bones Citric Acid src Homology Domains Organophosphorus Compounds Cyclohexanes Drug Discovery Animals Bone Resorption Enzyme Inhibitors Binding site Phosphotyrosine chemistry.chemical_classification Chemistry Molecular Mimicry Biological activity Durapatite Enzyme Benzamides Molecular Medicine Rabbits Signal transduction Protein Binding Proto-oncogene tyrosine-protein kinase Src |
| Zdroj: | Journal of Medicinal Chemistry. 44:660-663 |
| ISSN: | 1520-4804 0022-2623 |
| Databáze: | OpenAIRE |
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