Effects of Acupuncture Treatment on Fibromyalgia Symptoms, Serotonin, and Substance P Levels: A Randomized Sham and Placebo-Controlled Clinical Trial
| Autor: | Fatih Akçay, Saliha Karatay, Kadir Yildirim, Sibel Caglar Okur, Hulya Uzkeser |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Serotonin medicine.medical_specialty Fibromyalgia Visual analogue scale Acupuncture Therapy Substance P Placebo law.invention Young Adult 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Acupuncture Humans Pain Management Medicine Pain Measurement 030203 arthritis & rheumatology business.industry Beck Depression Inventory General Medicine Middle Aged medicine.disease Clinical trial Treatment Outcome Anesthesiology and Pain Medicine Nottingham Health Profile Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Pain Medicine. 19:615-628 |
| ISSN: | 1526-4637 1526-2375 |
| DOI: | 10.1093/pm/pnx263 |
| Popis: | Objective The aim of this study was to evaluate the effects of acupuncture treatment on serum levels of serotonin and substance P (SP) as well as on clinical parameters in patients with fibromyalgia (FM). Methods This is a randomized controlled clinical trial. Seventy-five women with FM were randomized into one of three kinds of acupuncture treatment: real acupuncture group (AcG), sham acupuncture group (ShG), and simulated acupuncture group (SiG). Treatments were applied semiweekly for four weeks. The serum levels of serotonin and SP were evaluated before and after the eight sessions. Patients were clinically assessed by visual analog scale (VAS), the number of tender points (NTP), Fibromyalgia Impact Questionnaire (FIQ), Beck Depression Inventory (BDI), and Nottingham Health Profile (NHP) at baseline, after the last treatment, and one and three months after completion of all treatments. Results Serum serotonin values increased significantly after treatment in AcG and ShG (P |
| Databáze: | OpenAIRE |
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