Characterization of Molecular Genetic Alterations in GBMs Highlights a Distinctive Molecular Profile in Young Adults
| Autor: | Geetika Singh, Suvendu Purkait, Pankaj Jha, Deepak Gupta, Vikas Sharma, Pankaj Pathak, Chitra Sarkar, Vaishali Suri, Mehar Chand Sharma, Ashish Suri, Ashok Kumar Mahapatra, Prerana Jha |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Aging IDH1 Adolescent Pathology and Forensic Medicine Young Adult Gene duplication Genetic variation Humans PTEN Epidermal growth factor receptor Young adult Child neoplasms Molecular Biology Sequence Deletion Chromosome Aberrations biology Brain Neoplasms Gene Expression Profiling Gene Amplification PTEN Phosphohydrolase Genetic Variation Histology Cell Biology Middle Aged Isocitrate Dehydrogenase nervous system diseases ErbB Receptors Gene expression profiling Mutation Cancer research biology.protein Female Tumor Suppressor Protein p53 Glioblastoma |
| Zdroj: | Diagnostic Molecular Pathology. 20:225-232 |
| ISSN: | 1052-9551 |
| Popis: | To evaluate age-related differences in histopathologic and molecular profile of glioblastomas (GBMs) at various age groups, with special reference to TP53 mutation, epidermal growth factor receptor (EGFR) amplification, EGFR vIII mutant, PTEN deletion, and IDH1 mutation. Agewise GBM incidence was calculated over a period of 5 years (2005 to 2009). Seventy-five GBMs were selected for molecular analysis. Majority of cases were in the age group of 41 to 60 years, and mean age was 43.6 years. Histology of all 75 cases selected for molecular profiling was identical. Primary adult GBMs showed EGFR amplification and PTEN deletion in majority (37.3% and 54.9%, respectively). TP53 and IDH1 mutations were rare (11.8% cases each). In secondary GBMs, TP53 (66.7%) and IDH1 mutations (44.4%) were most frequent. PTEN deletion was seen in 33.3% and none had EGFR amplification. Pediatric GBMs ( |
| Databáze: | OpenAIRE |
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