Association Studies of CYP1A1 Exon7 Polymorphism and -GSTM1 Interaction with Esophageal Cancer Risk: a Meta-Analysis in the Chinese Population
| Autor: | Da-Feng Xu, Xin-Ping Chen, Sheng-Miao Fu, Weihua Xu, Jia Yao, Zhichao Ma |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology China medicine.medical_specialty Esophageal Neoplasms Population General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Asian People Risk Factors Internal medicine Genotype Epidemiology Cytochrome P-450 CYP1A1 Odds Ratio medicine Humans Genetic Predisposition to Disease education Glutathione Transferase Genetic association education.field_of_study Polymorphism Genetic business.industry Exons Odds ratio Esophageal cancer medicine.disease Confidence interval 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis Meta-analysis Mutation business Gene Deletion |
| Zdroj: | Clinical Laboratory. 62 |
| ISSN: | 1433-6510 |
| DOI: | 10.7754/clin.lab.2016.160132 |
| Popis: | BACKGROUND Although many epidemiological studies have investigated the CYP1A1 exon7 polymorphism and -GSTM1 interaction with esophageal cancer (EC), definite conclusions cannot be drawn. This study was conducted to explore this association in the Chinese population using meta-analysis. METHODS Relevant studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure, and Chinese Biology Medicine databases published through August 2015. The association of CYP1A1 exon7 polymorphisms and EC risk was estimated by odds ratio (ORs) with 95% confidence intervals (CIs). In addition, the interaction between the CYP1A1 exon7 and GSTM1 genotypes was assessed. RESULTS A total of 13 case-control studies including 1781 EC cases and 1996 controls were included in this metaanalysis. Overall, significantly increased EC risk was associated with the CYP1A1 exon7 polymorphism (G vs. A OR = 1.36, 95% CI = 1.14 - 1.64; GG vs. AA: OR = 1.85, 95% CI = 1.22 - 2.79; GG vs. AG: OR = 1.41, 95% CI = 1.01 - 1.96; GG + AG vs. AA: OR = 1.47, 95% CI = 1.28 - 1.68; GG vs. AA + AG: OR = 1.60, 95% CI = 1.10 - 2.31). In a subgroup analyses stratified by geographic areas, histopathology type and source of controls, the significant risk was found in hospital-based population, in South and North China. Analysis of CYP1A1- GSTM1 interaction did find synergistic interaction between these two genes. CONCLUSIONS This meta-analysis provides the evidence that CYP1A1 exon7 polymorphism may contribute to the EC development in the Chinese population, and CYP1A1- GSTM1 interaction might elevate the risk. |
| Databáze: | OpenAIRE |
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