A rare coexistence of papillary carcinoma and anaplastic carcinoma of thyroid in multinodular goitre: Case report and literature review
| Autor: | Dipendra Gautam, Tika Ram Bhandari, Tridip Pantha, Sudha Shahi |
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| Rok vydání: | 2020 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases medicine.medical_treatment Case Report Papillary carcinoma Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine medicine Adjuvant therapy Anaplastic carcinoma Multiodular goiter Mixed tumor business.industry Thyroid Anaplastic thyroid carcinoma Neck dissection General Medicine medicine.disease Multinodular goitre medicine.anatomical_structure 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Surgery Coexitent tumors Radiology Differential diagnosis business |
| Zdroj: | Annals of Medicine and Surgery |
| ISSN: | 2049-0801 |
| Popis: | Introduction Multinodular goiter is defined as multiple discrete nodules in the thyroid gland. The incidence of Papillary carcinoma thyroid was found to be highest out of total Multinodular Goiter cases while that of Anaplastic carcinoma was the least. We report a rare coexistence of Papillary carcinoma and Anaplastic carcinoma in adult patient with a long-standing Multinodular Goiter. Case presentation Here we present a case of 54 years male with huge anterior neck swelling for 20 years with a gradual increase in size. Computerized tomography of neck revealed solidocystic mass lesion without any significant lymphadenopathy, features suggesting Multinodular goiter with differential diagnosis of Carcinoma Thyroid. Cytological examination showed Papillary thyroid Carcinoma. He underwent total thyroidectomy with central neck dissection. Postoperative period was uneventful. Histopathological report revealed features suggestive of mixed tumor of Papillary thyroid Carcinoma and Anaplastic Carcinoma thyroid TNM Staging T3 N0 M0, Stage IVA. After the final reports patient was sent for adjuvant therapy three weeks later where he received megavoltage external beam radiation and he was followed up till 12th week. He was assessed radiologically which showed no signs of physical progression of the disease. However, he was lost to follow up after that visit. Discussion Long-standing benign conditions of thyroid can transform into malignant forms in the undefined duration of time. Conclusion Regular follow up and early management of multinodular goiter at the right time can save a patient from undue stress and complication like the conversion into malignancy. |
| Databáze: | OpenAIRE |
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