The Role of Anabolic Androgenic Steroids in Disruption of the Physiological Function in Discrete Areas of the Central Nervous System
| Autor: | Giuseppe Bertozzi, Mohsin H. K Roshan, Renato Bernardini, Giuseppe Davide Albano, Francesco Sessa, Gabriele Sani, Roberto Avola, Monica Salerno, Francesca Maglietta, Cristoforo Pomara, Giovanni Li Volti |
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| Přispěvatelé: | Bertozzi, Giuseppe, Sessa, Francesco, Albano, Giuseppe Davide, Sani, Gabriele, Maglietta, Francesca, Roshan, Mohsin H K, Volti, Giovanni Li, Bernardini, Renato, Avola, Roberto, Pomara, Cristoforo, Salerno, Monica |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Neuroscience (miscellaneous) Serotonergic Abuse Amygdala Anabolic-androgenic steroids (AAS) Behavioral disorders Central nervous system Molecular mechanisms Cellular and Molecular Neuroscience Molecular mechanism 03 medical and health sciences Anabolic Agents 0302 clinical medicine medicine Animals Humans Direct pathway of movement Aggression Central nucleus of the amygdala Dopaminergic 030104 developmental biology medicine.anatomical_structure Neurology Hypothalamus Behavioral disorder Androgens Anxiety Steroids medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery |
| Popis: | Anabolic-androgenic steroids (AAS) abuse is often associated with a wide spectrum of adverse effects. These drugs are frequently abused by adolescents and athletes for esthetic purposes, as well as for improvement of their endurance and performances. In this literature review, we evaluated the correlation between AAS and anxiety or aggression. Two pathways are thought to be involved in AAS-induced behavioral disorders. Direct pathway via the amygdalo-fugal pathway, which connects the central nucleus of the amygdala to the brainstem, is involved in cognitive-emotive and homeostatic processes. The latter is modified by chronic AAS use, which subsequently leads to increased anxiety. Indirect pathways via the serotonergic, dopaminergic, and glutamatergic signals which are modified by AAS abuse in latero-anterior hypothalamus and can mediate the aggressive behavior. In conclusion, the molecular mechanisms underlying the behavioral alterations following AAS abuse is unclear and remains ambiguous as additional long-term studies aimed to understand the precise mechanisms are required. |
| Databáze: | OpenAIRE |
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