Long-term mortality and quality of life after septic shock: a follow-up observational study

Autor: Yannick Mallédant, Jeff Morcet, Nicolas Nesseler, Anne Defontaine, Yoann Launey, Philippe Seguin
Přispěvatelé: Foie, métabolismes et cancer, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de réanimation chirurgicale, Université de Rennes (UR)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Touya, Véronique, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
[SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery
Critical Care and Intensive Care Medicine
law.invention
Hospitals
University
0302 clinical medicine
Short-form 36
Quality of life
Risk Factors
law
Surveys and Questionnaires
Septic shock
Health Status Indicators
Prospective Studies
030212 general & internal medicine
Prospective cohort study
Outcome
Aged
80 and over
education.field_of_study
Age Factors
Middle Aged
Shock
Septic
Intensive care unit
humanities
3. Good health
Intensive Care Units
SAPS II
Shock (circulatory)
Female
France
medicine.symptom
medicine.medical_specialty
Population
[SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery
Statistics
Nonparametric
03 medical and health sciences
Internal medicine
medicine
Humans
Mortality
Intensive care medicine
education
Aged
Chi-Square Distribution
business.industry
030208 emergency & critical care medicine
Length of Stay
medicine.disease
Logistic Models
business
Chi-squared distribution
Zdroj: Intensive Care Medicine
Intensive Care Medicine, 2013, 39 (5), pp.881-888. ⟨10.1007/s00134-013-2815-1⟩
Intensive Care Medicine, Springer Verlag, 2013, 39 (5), pp.881-888. ⟨10.1007/s00134-013-2815-1⟩
ISSN: 0342-4642
1432-1238
DOI: 10.1007/s00134-013-2815-1⟩
Popis: International audience; PURPOSE: In septic shock, short-term outcomes are frequently reported, while long-term outcomes are not. The aim of this study was to evaluate mortality and health-related quality of life (HRQOL) in survivors 6 months after an episode of septic shock. METHODS: This single-centre observational study was conducted in an intensive care unit in a university hospital. All patients with septic shock were included. Mortality was assessed 6 months after the onset of septic shock, and a comparison between patients who survived and those who died was performed. HRQOL was assessed using the MOS SF-36 questionnaire prior to hospital admission (baseline) and at 6 months in survivors. HRQOL at baseline and at 6 months were compared to the general French population, and HRQOL at baseline was compared to 6-month HRQOL. RESULTS: Ninety-six patients were included. Six-month mortality was 45 %. Survivors were significantly younger, had significantly lower lactate levels and SAPS II scores, required less renal support, received less frequent administration of corticosteroids, and had a longer length of hospital stay. At baseline (n = 39) and 6 months (n = 46), all of the components of the SF-36 questionnaire were significantly lower than those in the general population. Compared to baseline (n = 23), the Physical Component Score (CS) improved significantly at 6 months, the Mental CS did not differ. CONCLUSIONS: Mortality 6 months after septic shock was high. HRQOL at baseline was impaired when compared to that of the general population. Although improvements were noted at 6 months, HRQOL remained lower than that in the general population.
Databáze: OpenAIRE
Externí odkaz: