Carcinoembryonic antigen and matrix metalloproteinase 2 serum and peritoneal washes concentration in staging and prognosis in colorectal cancer patients
| Autor: | Maciej Słodkowski, Marzena Iwanowska, Gustaw Lech, Marek Wroński, Dagmara Mirowska-Guzel, Tomasz Guzel |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty MMP2 endocrine system diseases Colorectal cancer Matrix metalloproteinase Gastroenterology Carcinoembryonic antigen Internal medicine Statistical significance Biomarkers Tumor medicine Humans Postoperative Period neoplasms Survival rate Aged Neoplasm Staging biology business.industry General Medicine Middle Aged Prognosis medicine.disease digestive system diseases Carcinoembryonic Antigen Survival Rate Colonic Neoplasms Preoperative Period Curative surgery biology.protein Matrix Metalloproteinase 2 Female Surgery Peritoneum Colorectal Neoplasms business Carcinoembryonal antigen |
| Zdroj: | Polish Journal of Surgery. 90:36-43 |
| ISSN: | 2299-2847 0032-373X |
| Popis: | Purpose: The aim of the study was to determine of carcinoembryonal antigen and matrix metalloproteinase 2 peritoneal washes and serum concentration in patients suffering from colorectal cancer concerning tumor staging and 5-year survival rate in these patients. Methods: 80 patients who underwent curative surgery for colorectal cancer were included into the study. Preoperative serum and intraoperative peritoneal washes CEA and MMP-2 concentrations were measured. Results: Concerning tumor penetration CEA-s and CEA-p concentration was higher in subsequent stages from T2 to T4. Both CEA-s and CEA-p concentration was lower in T2 comparing to T3 and T4. Significant difference of CEA-s and CEA-p was noted between T2 and T4 stages. MMP2-s concentration was higher in T3 comparing to T2, the highest MMP2-p concentration was in T4, with no statistical significance. Concerning nodular status significant difference of CEA-s was noted between N0 and N1. For CEA-p significance was found between N0 and N2 as between N1 and N2. MMP2-s concentration was the highest in N1, MMP2-p concentration was the highest in T4, with no statistical significance. 5-year survival rate for all patients was 63,53%. There were significant differences in CEA-s and CEA-p concentration between patients with negative and positive 5-year survival. Conclusion: Intraoperative peritoneal washes concentration of CEA may potentially serve as an important factor for more precise colorectal cancer staging. CEA-p and CEA-s concentration correlates with survival rate in patients suffering from colorectal cancer and can be useful as an additional prognostic factor. Usefulness of MMP2 measurement still requires further studies. |
| Databáze: | OpenAIRE |
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