Association of A1166C polymorphism in AT(1) receptor gene with baroreflex sensitivity
| Autor: | Zuzana Nováková, Eva Závodná, Bohumil Fišer, Miroslav Jíra, Lydie Izakovičová Hollá, Nataša Honzíková, Anna Vašků |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Physiology Blood Pressure 030204 cardiovascular system & hematology Baroreflex Polymorphism Single Nucleotide Risk Assessment Receptor Angiotensin Type 1 03 medical and health sciences Young Adult 0302 clinical medicine Gene Frequency Heart Rate Risk Factors Internal medicine A1166c polymorphism medicine Odds Ratio Humans Spectral analysis Receptor Czech Republic Genetics Chemistry Homozygote Blood Pressure Determination Signal Processing Computer-Assisted General Medicine Endocrinology Phenotype Female 030217 neurology & neurosurgery |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0862-8408 |
| Popis: | The aim of this study was to evaluate the association of A1166C polymorphism in angiotensin II type 1 receptor (AT1R) gene with baroreflex sensitivity (BRS in ms/mm Hg; BRSf in mHz/mm Hg) in man. BRS and BRSf were determined by a spectral method in 135 subjects (19-26 years) at a frequency of 0.1 Hz. Genotypes were detected by means of polymerase chain reaction and restriction analysis using enzyme DdeI. We compared BRS and BRSf among genotypes of this polymorphism. The frequency of genotypes of AT1R A1166C polymorphism was: 45.9 % (AA, n=62), 45.9 % (AC, n=62), 8.2 % (CC, n=11). Differences in BRS (p |
| Databáze: | OpenAIRE |
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