Changes of adiponectin and inflammatory cytokines after periodontal intervention in type 2 diabetes patients with periodontitis

Autor: Guang-Ming Qin, Wei-Lian Sun, Yue-Zhong Ren, Li-li Chen, Su-Zhan Zhang
Rok vydání: 2010
Předmět:
Carotid Artery Diseases
Male
endocrine system diseases
Type 2 diabetes
Gastroenterology
Surgical Flaps
Root Planing
Impaired glucose tolerance
Macrovascular disease
Peripheral Vascular Diseases
biology
General Medicine
Middle Aged
C-Reactive Protein
Female
Adiponectin
Inflammation Mediators
Adult
medicine.medical_specialty
Heart Diseases
Diabetes mellitus
Internal medicine
Glucose Intolerance
Periodontal Attachment Loss
medicine
Humans
Periodontal Pocket
Periodontitis
General Dentistry
Aged
Glycated Hemoglobin
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
C-reactive protein
nutritional and metabolic diseases
Type 2 Diabetes Mellitus
Cell Biology
Atherosclerosis
medicine.disease
Endocrinology
Diabetes Mellitus
Type 2
Otorhinolaryngology
biology.protein
Dental Scaling
Gingival Hemorrhage
business
Diabetic Angiopathies
Follow-Up Studies
Zdroj: Archives of Oral Biology. 55:970-974
ISSN: 0003-9969
DOI: 10.1016/j.archoralbio.2010.08.001
Popis: To determine serum adiponectin, C-reactive protein (CRP), TNF-α and IL-6 levels in impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) patients with periodontitis before and after periodontal intervention, and to investigate the relationship between T2DM and periodontitis.A total of 50 IGT and 106 T2DM patients with periodontitis were enrolled. The T2DM patients were divided into two groups: T2DM without macrovascular disease (DM1) group and T2DM with macrovascular disease (DM2) group. Each group was randomly divided into two subgroups according to whether they performed periodontal intervention. The normal control group (NC group) consisted of 30 healthy adults. The serum adiponectin, CRP, TNF-α and IL-6 levels were measured at baseline and 3 months after periodontal intervention.The serum adiponectin levels at baseline had decreased tendency with significant difference between each two groups, while CRP, TNF-α, and IL-6 levels had increased tendency with significant difference between each two groups among NC, IGT, DM1 and DM2 groups (all P0.01). At 3 months after periodontal intervention, the serum adiponectin levels were increased than those without periodontal intervention (all P0.01), while CRP, IL-6 and TNF-α significantly decreased (all P0.05) in both IGT and DM1 groups. In DM2 group, only CRP levels at 3 months after periodontal intervention were significantly decreased (P0.05). Moreover, the HbAlc levels in T2DM patients were improved at 3 months after periodontal invention (P0.01).Periodontal intervention is helpful for glucose control, which may be associated with increased serum adiponectin levels and decreased inflammatory cytokine levels.
Databáze: OpenAIRE
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