Synthesis of α-Phosphorylated α,β-Unsaturated Imines and Their Selective Reduction to Vinylogous and Saturated α-Aminophosphonates

Autor:	Francisco Palacios, Domitila Aparicio, Agnieszka Maliszewska, Javier Vicario
Rok vydání:	2007
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Yield (chemistry) Organic Chemistry Imine Chemical reduction Phosphorylation Selective reduction General Medicine Selectivity Medicinal chemistry Chemical synthesis
Zdroj:	The Journal of Organic Chemistry. 72:2682-2685
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo062609+
Popis:	An efficient synthesis of α,β-unsaturated imines derived from α-aminophosphonates is achieved through aza-Wittig reaction of P-trimethyl phosphazenes with β,γ-unsaturated α-ketophosphonates. Selective 1,2-reduction of such 1-azadienes affords β,γ-unsaturated α-aminophosphonates, phosphorylated analogs of vinylglycines, which are hydrogenated to yield saturated α-aminophosphonate derivatives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8f230b55a1aedbcf18af38c1b2eb71 https://doi.org/10.1021/jo062609+ Zobrazit plný text záznamu