Topical bupivacaine and etidocaine analgesia following fallopian tube banding
| Autor: | Nonita T. Lim Uy, Ray McKenzie, Jagadamba Chalasani, Brian M. Melnick, Preyaratt Phitayakorn, Albert F. Vicinie, Roland L. Kennedy |
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| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Time Factors Sterilization Tubal Etidocaine medicine.drug_class Administration Topical Uterus Random Allocation Double-Blind Method medicine Humans General anaesthesia Laparoscopy Fallopian Tubes Bupivacaine Clinical Trials as Topic Pain Postoperative Tubal ligation medicine.diagnostic_test business.industry Local anesthetic General Medicine Abdominal Pain Surgery Anesthesiology and Pain Medicine medicine.anatomical_structure Anesthesia Acetanilides Female business Anesthesia Local medicine.drug Fallopian tube |
| Zdroj: | Canadian Journal of Anaesthesia. 36:510-514 |
| ISSN: | 1496-8975 0832-610X |
| Popis: | The purpose of this study was to compare the effectiveness and safety of etidocaine and bupivacaine for postoperative analgesia after laparoscope sterilization. The study was performed in 22 healthy patients who received either one per cent etidocaine, 2 mg.kg-1, or bupivacaine 1.5 mg.kg-1 in a double-blind, randomized fashion. The local anaesthetic was dropped onto the fallopian tubes from uterus to fimbriae before tubal occlusion. To establish safety, blood concentrations of the parent drug and its metabolites were measured before application and at 1, 3, 6, 10, 15, 30, 60 and 120 min. The mean peak concentrations were 501.8 +/- 71.3 (SEM) for etidocaine with a range of 225 to 905 ng.ml-1. For bupivacaine, the mean peak concentration was 468 +/- 73.8 SEM with a range from 191 to 1005 ng.ml-1. The mean values are one eighth of the toxic convulsive dose for humans. Etidocaine was metabolized at a faster rate than bupivacaine with a rapid appearance of 2-amino-2'-butyroxylidide (ABX). The bupivacaine metabolite 2,6-pipecoloxylidide (PPX) was detected in low concentrations in the 60-minute samples. We conclude that the topical application of either etidocaine or bupivacaine is a safe procedure in the doses and concentrations used during general anaesthesia for laparoscopic tubal banding. |
| Databáze: | OpenAIRE |
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