Carboplatin and paclitaxel in metastatic or recurrent cervical cancer
| Autor: | Amanda Psyrri, Eirini Pectasides, George Papaxoinis, Dimitrios Pectasides, John Panayiotides, George Fountzilas, Anna Koumarianou, Theofanis Economopoulos, Constantinos Sykiotis, Nicolaos Xiros |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Paclitaxel Uterine Cervical Neoplasms Neutropenia Gastroenterology Disease-Free Survival Carboplatin chemistry.chemical_compound Internal medicine Antineoplastic Combined Chemotherapy Protocols Carcinoma medicine Humans Cervix Aged Retrospective Studies Performance status business.industry Area under the curve Obstetrics and Gynecology Middle Aged medicine.disease Recurrent Cervical Carcinoma medicine.anatomical_structure Oncology chemistry Carcinoma Squamous Cell Female Neoplasm Recurrence Local business Febrile neutropenia |
| Zdroj: | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 19(4) |
| ISSN: | 1525-1438 |
| Popis: | Objectives: The purpose of this study was to evaluate the activity and toxicity of carboplatin and paclitaxel combination in advanced or recurrent carcinoma of the cervix. Methods: Fifty-one eligible patients with measurable advanced or recurrent cervical carcinoma were treated with carboplatin (area under the curve, 5) and paclitaxel 175 mg/m2 every 3 weeks for 6 to 9 cycles or until disease progression or unacceptable toxicity. Results: Eight complete (16%) and 19 partial responses (37%) occurred, for an overall response rate (RR) of 53% (95% confidence interval [CI], 39%-67%). The median progression-free survival was 6 months (95% CI, 5.4-6.5 months), and the median overall survival was 13 months (95% CI, 11.4-14.5 months). The RR was higher in patients with disease outside a previously irradiated site compared with those with disease in a previously irradiated field (68% vs 30%) (P = 0.011). Patients previously treated with chemoradiation had an RR of 28%, whereas in those previously treated with radiotherapy alone, the RR was 68% (P = 0.023). There was no statistically significant difference between histology and response to therapy. Patients with performance status of 0 or 1 had a higher RR than those with worse performance status. Toxicity was generally mild except for myelotoxicity. Neutropenia grade 3/4 was recorded in 44% of patients, and 6% experienced febrile neutropenia. Twenty-two percent of patients experienced anemia grade 3-4, whereas 14% had thrombocytopenia grade 3-4. Three patients (6%) developed grade 3 sensory neuropathy. Conclusion: The combination of carboplatin and paclitaxel seems to have activity in advanced or recurrent cervical carcinoma with an acceptable toxicity profile. |
| Databáze: | OpenAIRE |
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