Mechanism of Insulin Resistance in Normal Pregnancy
| Autor: | Pe Thelwall, Sc Robson, Roy Taylor, Kenneth Hodson, Claudio Cobelli, Chiara Dalla Man, Fe Smith |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Type 2 diabetes Biochemistry Endocrinology Insulin resistance Pregnancy Internal medicine Diabetes mellitus Medicine Humans Insulin Triglycerides business.industry Muscles Biochemistry (medical) General Medicine medicine.disease Obesity Gestational diabetes Lipoproteins LDL Female Insulin Resistance business Lipoprotein |
| Popis: | Normal pregnancy is associated with insulin resistance although the mechanism is not understood. Increased intramyocellular lipid is closely associated with the insulin resistance of type 2 diabetes and obesity, and the aim of this study was to determine whether this was so for the physiological insulin resistance of pregnancy. Eleven primiparous healthy pregnant women (age: 27-39 years, body mass index 24.0±3.1 kg/m2) and no personal or family history of diabetes underwent magnetic resonance studies to quantify intramyocellular lipid, plasma lipid fractions, and insulin sensitivity. The meal-related insulin sensitivity index was considerably lower in pregnancy (45.6±9.9 vs. 193.0±26.1; 10(-4) dl/kg/min per pmol/l, p=0.0002). Fasting plasma triglyceride levels were elevated 3-fold during pregnancy (2.3±0.2 vs. 0.8±0.1 mmol/l, p |
| Databáze: | OpenAIRE |
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