Long-term Follow-up of Patients With Acute Hypertriglyceridemia-Induced Pancreatitis
| Autor: | Nikolaos Eugenidis, Vassilios G. Athyros, Vassilios I. Bouloukos, Athanasios G. Kontopoulos, Olga Giouleme, Themistoklis Vasiliadis, Nikolaos Nikolaidis |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Pancreatic disease Alcohol abuse Gastroenterology Internal medicine Diabetes mellitus Secondary Prevention medicine Humans Prospective Studies Hypertriglyceridemia Pregnancy business.industry digestive oral and skin physiology nutritional and metabolic diseases Middle Aged medicine.disease Surgery Treatment Outcome Pancreatitis Acute Disease Acute pancreatitis Female lipids (amino acids peptides and proteins) Complication business |
| Zdroj: | Journal of Clinical Gastroenterology. 34:472-475 |
| ISSN: | 0192-0790 |
| DOI: | 10.1097/00004836-200204000-00020 |
| Popis: | An acute and potentially life-threatening complication of hypertriglyceridemia (HTG) is acute pancreatitis (AP). Hypertriglyceridemia, usually severe, may be primary in origin or secondary to alcohol abuse, diabetes mellitus, pregnancy, and use of drugs.The efficacy of treatment to prevent relapses in 17 patients with AP attributed to HTG was investigated in the current prospective study. The mean follow-up period of patients was 42 months. Hypertriglyceridemia-induced AP comprised 6.9% of all patients with AP (n = 246) hospitalized in our clinic during the study (6 years).Causative conditions of HTG-induced AP were familial HTG in eight patients, HTG caused by uncontrolled diabetes mellitus in five, HTG aggravated by drugs in two (one by tamoxifen and one by fluvastatin), familial hyperchylomicronemia (HCM) in one, and lipemia of pregnancy in one. During the acute phase of pancreatitis, patients underwent standard treatment. Thereafter, HTG was efficiently controlled with high dosages of fibrates or a fibrate plus acipimox, except for the patient with HCM, who was on a specific diet (the only source of fat was a special oil consisting of medium chain triglyceride) and taking a high dosage of acipimox. One of the patients died during the acute phase of pancreatitis with acute respiratory distress syndrome. During follow-up, maintenance treatment was successful and only one patient relapsed, because he discontinued diet and drug treatment.Appropriate diet and drug treatment, including dose titration, of severe HTG is very effective in preventing relapses of HTG-induced AP. |
| Databáze: | OpenAIRE |
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