Prognostic value of microsatellite instability determined by immunohistochemical staining of hMSH2 and hMSH6 in urothelial carcinoma of the bladder
| Autor: | A. Zarogiannos, Anastasios Zervas, Irene Nikolaou, Ioanna Giannopoulou, Lydia Nakopoulou, Alexandros Nomikos, Eleni Mylona |
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| Rok vydání: | 2008 |
| Předmět: |
Microbiology (medical)
Adult Male congenital hereditary and neonatal diseases and abnormalities Pathology medicine.medical_specialty Urinary Bladder Caspase 3 Biology DNA Mismatch Repair Pathology and Forensic Medicine medicine Carcinoma Biomarkers Tumor Immunology and Allergy Humans Aged Aged 80 and over Cell Nucleus Bladder cancer Cancer Microsatellite instability General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry digestive system diseases Staining DNA-Binding Proteins MutS Homolog 2 Protein Urinary Bladder Neoplasms DNA mismatch repair Female Microsatellite Instability Tumor Suppressor Protein p53 Urothelium |
| Zdroj: | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 116(1) |
| ISSN: | 0903-4641 |
| Popis: | Mismatch repair (MMR) genes are involved in the recognition and repair of acquired DNA damage, which arises during cell division, thus playing an essential role in preserving genetic stability. Immunohistochemistry was applied to 130 specimens from urothelial carcinoma (UC) of the bladder to detect expression of MMR gene products hMSH2 and hMSH6, and to investigate its clinicopathological and prognostic value. hMSH2 and hMSH6 protein expression was exclusively detected in the nuclei of malignant cells. Of the 112 cases evaluable for hMSH2, 29 (25.9%) were negative and of the 130 UCs evaluable for hMSH6, 64 (49.2%) were negative, and were thus considered to depict MSI. Nuclear hMSH2 values were statistically lower in non-invasive UCs (Ta-T1) (p=0.013) and in carcinomas with decreased p53 staining (p=0.04). Lower hMSH6 values were more often met in well-differentiated tumors (p |
| Databáze: | OpenAIRE |
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