Genetic Architecture of Plasma Adiponectin Overlaps With the Genetics of Metabolic Syndrome–Related Traits
| Autor: | Marijke Frölich, Irina V. Zorkoltseva, Cornelia M. van Duijn, Ben A. Oostra, Ko Willems van Dijk, Yurii S. Aulchenko, Peter Henneman, M. Carola Zillikens, Rune R. Frants |
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| Přispěvatelé: | Epidemiology, Internal Medicine, Clinical Genetics |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Cardiovascular and Metabolic Risk medicine.medical_specialty Endocrinology Diabetes and Metabolism Population Genome-wide association study Polymorphism Single Nucleotide Genetic correlation genome-wide linkage insulin-resistance association heritability sensitivity population obesity family adipoq Young Adult Insulin resistance SDG 3 - Good Health and Well-being Internal medicine Internal Medicine Humans Medicine education Aged Original Research Genetic association Aged 80 and over Metabolic Syndrome Advanced and Specialized Nursing Genetics education.field_of_study Adiponectin business.industry Genetics of obesity Cholesterol HDL nutritional and metabolic diseases Middle Aged medicine.disease C-Reactive Protein Endocrinology Female Insulin Resistance Metabolic syndrome business hormones hormone substitutes and hormone antagonists Genome-Wide Association Study |
| Zdroj: | Diabetes Care, 33(4), 908-913 Diabetes Care, 33(4), 908-913. American Diabetes Association Inc. Diabetes Care |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc09-1385 |
| Popis: | OBJECTIVE Adiponectin, a hormone secreted by adipose tissue, is of particular interest in metabolic syndrome, because it is inversely correlated with obesity and insulin sensitivity. However, it is not known to what extent the genetics of plasma adiponectin and the genetics of obesity and insulin sensitivity are interrelated. We aimed to evaluate the heritability of plasma adiponectin and its genetic correlation with the metabolic syndrome and metabolic syndrome–related traits and the association between these traits and 10 ADIPOQ single nucleotide polymorphisms (SNPs). RESEARCH DESIGN AND METHODS We made use of a family-based population, the Erasmus Rucphen Family study (1,258 women and 967 men). Heritability analysis was performed using a polygenic model. Genetic correlations were estimated using bivariate heritability analyses. Genetic association analysis was performed using a mixed model. RESULTS Plasma adiponectin showed a heritability of 55.1%. Genetic correlations between plasma adiponectin HDL cholesterol and plasma insulin ranged from 15 to 24% but were not significant for fasting glucose, triglycerides, blood pressure, homeostasis model assessment of insulin resistance (HOMA-IR), and C-reactive protein. A significant association with plasma adiponectin was found for ADIPOQ variants rs17300539 and rs182052. A nominally significant association was found with plasma insulin and HOMA-IR and ADIPOQ variant rs17300539 after adjustment for plasma adiponectin. CONCLUSIONS The significant genetic correlation between plasma adiponectin and HDL cholesterol and plasma insulin should be taken into account in the interpretation of genome-wide association studies. Association of ADIPOQ SNPs with plasma adiponectin was replicated, and we showed association between one ADIPOQ SNP and plasma insulin and HOMA-IR. |
| Databáze: | OpenAIRE |
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