Inducible Nitric Oxide Synthase Regulates Production of Isoprostanes In Vivo during Chlamydial Genital Infection in Mice
| Autor: | Kyle H. Ramsey, G. I. Byrne, S. V. Rana, J. D. Morrow, Ira M. Sigar, J. Gupta, Steven M. Holland |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Isoprostane Phagocyte Immunology Nitric Oxide Synthase Type II Chlamydia trachomatis Biology Microbiology Excretion Mice chemistry.chemical_compound In vivo Immunity Internal medicine medicine Animals Nitrite Nitrites Mice Knockout F2-Isoprostanes Phagocytes Host Response and Inflammation Vaginosis Bacterial Chlamydia Infections Isoprostanes Mice Inbred C57BL Nitric oxide synthase Infectious Diseases Endocrinology medicine.anatomical_structure Gene Expression Regulation chemistry biology.protein Female Parasitology Nitric Oxide Synthase Oxidoreductases |
| Zdroj: | Infection and Immunity. 71:7183-7187 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.71.12.7183-7187.2003 |
| Popis: | Urinary nitrite and F2-isoprostanes, an index of oxidant stress, were elevated during chlamydial genital infection of mice. Enhancement of urinary nitrite and F2-isoprostanes was observed in phagocyte oxidase-deficient mice. Inhibition of inducible nitric oxide synthase reduced isoprostane excretion. We conclude that nitrogen radicals induce F2-isoprostane production and excretion during murine chlamydial genital infection. |
| Databáze: | OpenAIRE |
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