Comparison between sublobar resection and 125Iodine brachytherapy after sublobar resection in high-risk patients with Stage I non–small-cell lung cancer
| Autor: | Athanasios Colonias, Susan Bartley, Mark Trombetta, David S. Parda, Robin S. Macherey, Robert J. Keenan, Tibetha S. Santucci, Rodney J. Landreneau, Ricardo S. Santos, Richard H. Maley |
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| Rok vydání: | 2003 |
| Předmět: |
Lung Neoplasms
Stage I Non-Small Cell Lung Cancer Radiography medicine.medical_treatment Brachytherapy Risk Assessment Iodine Radioisotopes Carcinoma Non-Small-Cell Lung medicine Carcinoma Humans Lung Postoperative Care High risk patients business.industry Incidence Respiratory disease medicine.disease Sublobar resection medicine.anatomical_structure Radiography Thoracic Surgery Neoplasm Recurrence Local Tomography X-Ray Computed Nuclear medicine business Follow-Up Studies |
| Zdroj: | Surgery. 134:691-697 |
| ISSN: | 0039-6060 |
| DOI: | 10.1016/s0039-6060(03)00327-1 |
| Popis: | Background Sublobar resection (SR) can be performed in high-risk non–small-cell lung carcinoma (NSCLC) patients but is associated with an increased local recurrence. This abstract reviews our intraoperative 125Iodine brachytherapy experience after SR in high-risk Stage I NSCLC patients and compares these results with our previous series of SR alone in similar patients. Methods One hundred two Stage I NSCLC patients who underwent SR alone were compared with 101 Stage I patients who underwent SR and intraoperative 125Iodine brachytherapy placed over the SR staple line. Conclusion Local recurrence after SR and 125Iodine brachytherapy (2%) in high-risk Stage I NSCLC patients was significantly less than after SR alone (18.6%). This safe, pulmonary function–preserving and practical intraoperative brachytherapy method should be considered when SR is used as a “compromise” therapy in these patients. |
| Databáze: | OpenAIRE |
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