Vaginal cuff brachytherapy in endometrial cancer – a technically easy treatment?
Autor: | I. Andres, Veronica Lopez-Honrubia, Meritxell Arenas, Sebastià Sabater, Marimar Sevillano, E. Jimenez-Jimenez, R. Berenguer, Angeles Rovirosa |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Brachytherapy Urology Rectum Review Late toxicity 03 medical and health sciences 0302 clinical medicine medicine rectum External beam radiotherapy bladder business.industry Endometrial cancer Postoperative radiation technique medicine.disease Vaginal cuff 030104 developmental biology medicine.anatomical_structure Oncology vaginal cuff brachytherapy 030220 oncology & carcinogenesis endometrial cancer Rectal distension Radiology business |
Zdroj: | Cancer Management and Research |
ISSN: | 1179-1322 |
Popis: | Endometrial cancer (EC) is one of the most common gynecological cancers among women in the developed countries. Vaginal cuff is the main location of relapses after a curative surgical procedure and postoperative radiation therapy have proven to diminish it. Nevertheless, these results have not translated into better survival results. The preeminent place of vaginal cuff brachytherapy (VCB) in the postoperative treatment of high- to intermediate-risk EC was given by the PORTEC-2 trial, which demonstrated a similar reduction in relapses with VCB than with external beam radiotherapy (EBRT), but VCB induced less late toxicity. As a result of this trial, the use of VCB has increased in clinical practice at the expense of EBRT. A majority of the clinical reviews of VCB usually address the risk categories and patient selection but pay little attention to technical aspects of the VCB procedure. Our review aimed to address both aspects. First of all, we described the risk groups, which guide patient selection for VCB in clinical practice. Then, we depicted several technical aspects that might influence dose deposition and toxicity. Bladder distension and rectal distension as well as applicator position or patient position are some of those variables that we reviewed. |
Databáze: | OpenAIRE |
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