Acetazolamide assisted Tc-99m MAG3 renography to assess renal blood flow reserve
Autor: | Yoshio Horita, Kazuki Fukuchi, Kouichi Taura, Masato Tadokoro, Masanobu Miyazaki, Yuhei Kawano, Kohei Hayashida, Shigeru Kohno, Shuichi Takishita, Naofumi Suyama |
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Rok vydání: | 2003 |
Předmět: |
Male
medicine.medical_specialty Urology Type 2 diabetes Kidney Essential hypertension Placebo Severity of Illness Index Renal Circulation Technetium Tc 99m Mertiatide Diabetes mellitus medicine Humans Radiology Nuclear Medicine and imaging business.industry General Medicine Effective renal plasma flow Middle Aged medicine.disease Surgery Acetazolamide Hypertension Renovascular medicine.anatomical_structure Diabetes Mellitus Type 2 Renal blood flow Hypertension Female Radiopharmaceuticals business Radioisotope Renography Blood Flow Velocity Diabetic Angiopathies medicine.drug |
Zdroj: | Annals of Nuclear Medicine. 17:139-144 |
ISSN: | 1864-6433 0914-7187 |
DOI: | 10.1007/bf02988452 |
Popis: | The present study examines whether or not baseline and acetazolamide (ACZ) Tc-99m MAG3 renography can assess renal blood flow reserve.Renography proceeded for 50 min after sequential injections of 370 MBq Tc-99m MAG3 for baseline renography and 10 min after a 1,000 mg injection of ACZ for ACZ renography. Effective renal plasma flow of renal cortex (cERPF) in each kidney and the percentage change in cERPF of those parameters (deltaERPF) were obtained before and after the administration of ACZ in 10 subjects without hypertension or diabetes (normal group), in 10 with essential hypertension (hypertensive group) and in 10 who had Type 2 diabetes with hypertension (diabetic group). A placebo test was performed in the 10 without hypertension or diabetes using distilled water instead of ACZ (placebo group).The placebo test performed in the 10 without hypertension or diabetes using distilled water instead of ACZ indicated that the parameter variance between the two types of renogram was below 3.2%. The cERPF of baseline and ACZ Tc-99m MAG3 renography and deltaERPF in the normal, hypertensive and diabetic groups were 89 +/- 10 and 110 +/- 10 ml/min, 89 +/- 14 and 117 +/- 22 ml/min, 100 +/- 23 and 112 +/- 23 ml/min, respectively, and 24.5 +/- 13.5%, 26.0 +/- 9.7% and 12.3 +/- 11.1%, respectively. The difference in the cERPF value was significant in the normal and hypertensive groups whereas this did not change in the diabetic group before or after ACZ administration.We suggested that the deltaERPF determined by baseline and ACZ Tc-99m MAG3 renography is a useful parameter for assessing renal blood flow reserve. |
Databáze: | OpenAIRE |
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