Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models
| Autor: | Beltrán Álvarez-Pérez, Anna Bagó-Mas, Meritxell Deulofeu, José Miguel Vela, Manuel Merlos, Enrique Verdú, Pere Boadas-Vaello |
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| Rok vydání: | 2022 |
| Předmět: |
Reserpine
Fibromyalgia Immunohistoquímica Pregabalin Chronic pain fibromyalgia reserpine gliosis sigma-1 receptor alpha-2-delta-1 subunit dark/light box test forced swimming test Hargreaves plantar test immunohistochemistry nociplastic pain Catalysis Inorganic Chemistry Mice Animals Receptors sigma Gliosis Physical and Theoretical Chemistry Molecular Biology Spectroscopy Analgesics Mice Inbred ICR Fibromiàlgia Pain -- Treatment Organic Chemistry General Medicine Dolor crònic Immunohistochemistry Computer Science Applications Disease Models Animal Hyperalgesia Female Dolor -- Tractament Chronic Pain |
| Zdroj: | International Journal of Molecular Sciences, 2022, vol. 23, núm. 19, p. 11933 Articles publicats (D-CM) Álvarez-Pérez, Beltrán Bagó Mas, Anna Deulofeu, Meritxell Vela, José Miguel Merlos, Manue Verdú Navarro, Enrique Boadas i Vaello, Pere 2022 Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models International Journal of Molecular Sciences 23 19 11933 DUGiDocs – Universitat de Girona instname International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11933 |
| Popis: | Sigma-1 receptor (σ1R) ligands have been shown to be effective at relieving neuropathic and inflammatory pain, but have not yet been tested in experimental models of fibromyalgia. The objective of this study was to evaluate the effect of a σ1R antagonist (BD1063) compared to pregabalin. ICR-CD1 female mice were subjected to either six repeated injections of reserpine, to cause reserpine-induced myalgia (RIM6), or acidified saline intramuscular injections (ASI). In these two models, we evaluated the effect of BD1063 and pregabalin on thermal hypersensitivity, anxiety-like and depression-like behaviors, and on spinal cord gliosis. BD1063 exerted an antinociceptive effect on both reflexive (thermal hyperalgesia) and nonreflexive (anxiety- and depression-like) pain behaviors, and reduced spinal astroglial and microglial reactivity, following repeated treatment for 2 weeks. Interestingly, the effects of BD1063 were long-term, lasting several weeks after treatment discontinuation in both fibromyalgia-like models. Similar results were obtained with pregabalin, but the effects on pain behaviors lasted for a shorter length of time, and pregabalin did not significantly modulate spinal glial reactivity. The inhibitory and long-lasting effect of pharmacological blockade of σ1Rs on both sensory and affective dimensions of nociplastic-like pain and spinal cord gliosis in two experimental models of fibromyalgia support the application of this therapeutic strategy to treat fibromyalgia This research was funded by ESTEVE Pharmaceuticals (Grant number 066/13 23/01/2017) and by the Vice-Chancellorship of Research of the University of Girona (Grant number MPCUdG2016/087) |
| Databáze: | OpenAIRE |
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