Prevalence of hyperhomocysteinaemia and some of its major determinants in Shaanxi Province, China: a cross-sectional study
| Autor: | Xiping Xu, Bo Wang, Xin Xu, Yue-Yun Ma, Gang Zhao, Bin Gao, Dong Sun, Zhirong Liu, Ming Shi, Xuedong Liu, Qiu-He Ji |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male China Pediatrics medicine.medical_specialty Homocysteine Cross-sectional study Hyperhomocysteinemia Medicine (miscellaneous) Physical examination Folic Acid Deficiency Cohort Studies Young Adult chemistry.chemical_compound Folic Acid Risk Factors Polymorphism (computer science) Prevalence Humans Medicine Genetic Predisposition to Disease Genetic Association Studies Methylenetetrahydrofolate Reductase (NADPH2) Aged Aged 80 and over Polymorphism Genetic Nutrition and Dietetics biology medicine.diagnostic_test business.industry Plasma levels Middle Aged Nutrition Surveys Cross-Sectional Studies Lifestyle factors chemistry Methylenetetrahydrofolate reductase biology.protein Female Gene polymorphism business Demography |
| Zdroj: | British Journal of Nutrition. 113:691-698 |
| ISSN: | 1475-2662 0007-1145 |
| DOI: | 10.1017/s0007114514004218 |
| Popis: | The aim of the present study was to investigate the prevalence of hyperhomocysteinaemia (HHCY; total plasma homocysteine (tHcy) concentration >15 μmol/l) and its major determinants in healthy Chinese northerners. A descriptive and cross-sectional study was conducted in Shaanxi Province, China. The study sample included 2645 participants (1042 men and 1603 women) aged >20 years. Demographic characteristics and lifestyle factors were assessed via questionnaire interviews and physical examination. Plasma levels of homocysteine and folate and methylenetetrahydrofolate reductase (MTHFR) gene polymorphism were determined according to standard methods. The prevalence of HHCY was 67·7 % (81·4 % in men and 58·8 % in women). The geometric mean of tHcy concentration was 19·1 μmol/l. The OR of HHCY were 0·44 (95 % CI 0·34, 0·57) for women v. men; 1·95 (95 % CI 1·41, 2·70), 1·41 (95 % CI 1·05, 1·88) and 0·76 (95 % CI 0·64, 0·89) for participants with smoking and alcohol drinking cessation and improved physical activity levels, respectively; 0·25 (95 % CI 0·17, 0·38), 0·33 (95 % CI 0·22, 0·49) and 0·56 (95 % CI 0·36, 0·88) for participants with an education level of elementary school, secondary school and university v. illiterate, respectively; 1·41 (95 % CI 1·13, 1·75) and 3·05 (95 % CI 2·35, 3·97) for participants with CT and TT v. CC genotype at MTHFR 677C → T polymorphism, respectively. These results demonstrate that the prevalence of HHCY is considerably high in Chinese northerners, especially in TT subjects, suggesting that implementation of tHcy-lowering strategies, such as lifestyle changes, is necessary. |
| Databáze: | OpenAIRE |
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