Simultaneous injection of hepatitis B vaccine with BCG and killed poliovirus vaccine
| Autor: | C. Bourdil, J. P. Chiron, Marie-Pascale Frenkiel, B. Yvonnet, Pierre Coursaget, S. Guindo, E. Jeannée, L. Teulières, Edgar H. Relyveld, A. Brizard, I. Diop-Mar, B. Fritzell |
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| Rok vydání: | 1992 |
| Předmět: |
Viral Hepatitis Vaccines
HBsAg Hepatitis B vaccine medicine.disease_cause complex mixtures medicine Humans Hepatitis B Vaccines Duck embryo vaccine Hepatitis B virus General Veterinary General Immunology and Microbiology business.industry Poliovirus Infant Newborn Public Health Environmental and Occupational Health Hepatitis B medicine.disease Virology Vaccination Poliovirus Vaccine Inactivated Infectious Diseases Vaccines Inactivated Immunization Immunology BCG Vaccine Molecular Medicine business |
| Zdroj: | Vaccine. 10:319-321 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/0264-410x(92)90370-y |
| Popis: | In most developing countries, hepatitis B virus is endemic and prevention has to be carried out early in life and on a mass scale. In these regions, simultaneous administration of multiple antigens is normal practice. We have therefore investigated the interaction of hepatitis B vaccine with BCG and inactivated polio vaccine. The serological antibody response to poliovirus and HBsAg as well as the cellular immune response to tuberculin post BCG immunization were assessed. The immune responses to HBsAg, BCG and polio vaccines injected simultaneously were comparable to those observed after separate administration of each vaccine. Moreover, no increase of adverse reactions was noted. Results confirmed that HB vaccine could be introduced into the WHO expanded programmes on immunization without impairing the expected protective efficacy against the targeted vaccine-preventable diseases. |
| Databáze: | OpenAIRE |
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