Targeting Neurovascular Interaction in Retinal Disorders
| Autor: | Ye Sun, David A. Antonetti, Zhongxiao Wang, Chi-Hsiu Liu, Timothy S. Kern, Ann Hellström, Yohei Tomita, William Britton, Steve S Cho, Lois E.H. Smith, Zhongjie Fu, Shuo Huang, Bertan Cakir |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
retina genetic structures Angiogenesis Review Retinal Neovascularization Neurodegenerative Mitochondrion Eye lcsh:Chemistry angiogenesis chemistry.chemical_compound 0302 clinical medicine 2.1 Biological and endogenous factors Medicine Aetiology lcsh:QH301-705.5 Spectroscopy photoreceptors General Medicine Mitochondria Computer Science Applications medicine.anatomical_structure medicine.symptom Blood Flow Velocity Photoreceptor Cells Vertebrate Retinal Disorder Inflammation energy shortage Catalysis Inorganic Chemistry 03 medical and health sciences Retinal Diseases Genetics Animals Humans Photoreceptor Cells Physical and Theoretical Chemistry Eye Disease and Disorders of Vision Molecular Biology Retina Chemical Physics Vertebrate business.industry Organic Chemistry Neurosciences Retinal Vessels Retinal Neurovascular bundle eye diseases 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 chemistry inflammation sense organs Choroid Other Biological Sciences Reactive Oxygen Species Other Chemical Sciences business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | International journal of molecular sciences, vol 21, iss 4 International Journal of Molecular Sciences, Vol 21, Iss 4, p 1503 (2020) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms21041503 |
| Popis: | The tightly structured neural retina has a unique vascular network comprised of three interconnected plexuses in the inner retina (and choroid for outer retina), which provide oxygen and nutrients to neurons to maintain normal function. Clinical and experimental evidence suggests that neuronal metabolic needs control both normal retinal vascular development and pathological aberrant vascular growth. Particularly, photoreceptors, with the highest density of mitochondria in the body, regulate retinal vascular development by modulating angiogenic and inflammatory factors. Photoreceptor metabolic dysfunction, oxidative stress, and inflammation may cause adaptive but ultimately pathological retinal vascular responses, leading to blindness. Here we focus on the factors involved in neurovascular interactions, which are potential therapeutic targets to decrease energy demand and/or to increase energy production for neovascular retinal disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |