Endometrial histology and progesterone levels in women using norethindrone acetate implants for contraception
| Autor: | G. Kinra, V. Hingorani, D. Takkar, Kesho R. Laumas, S. Jeyaseelan |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
medicine.medical_specialty media_common.quotation_subject Uterus Endometrium Andrology Internal medicine medicine Humans Endocrine system Ovulation Progesterone media_common Drug Implants medicine.diagnostic_test urogenital system Genitourinary system business.industry Obstetrics and Gynecology Norethindrone Acetate medicine.anatomical_structure Endocrinology Reproductive Medicine Female Norethindrone business Endometrial biopsy Hormone |
| Zdroj: | Contraception. 17:103-113 |
| ISSN: | 0010-7824 |
| DOI: | 10.1016/0010-7824(78)90066-5 |
| Popis: | The effect of a single implant-D containing 40 mg of norethindrone acetate on the endometrium and serum progesterone, and its mode of contraceptive action was investigated. 20 women aged 20-40 (parity 1-5) had used implant-D for periods of 7-27 months. Endometrial biopsies and peripheral venous bloods were collected between the 16th-28th days of the menstrual cycle. Endometrial dating was done according to the criteria of Noyes et al. 19 of the 20 biopsies taken showed the endometrium in the secretory phase, and serum progesterone levels above 3 ng/ml confirming that ovulation had occurred. The biopsy of the remaining woman showed proliferative endometrium and serum progesterone of 2.15 ng/ml. The dating of the endometrium revealed disparity between stromal, glandular, and vascular components of the specimens; thus, only approximate dates could be assigned to a particular specimen. In the dating of the endometrium, 5 women showed retardation by more than 3 days and 4 women showed enhancement of 3 or more days. The results show that the norethindrone-acetate-containing silastic implant-D does not inhibit ovulation and 1 mode of its interaction in fertility control is by bringing about an imbalance in endometrial maturation during the luteal phase. |
| Databáze: | OpenAIRE |
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