Stromal biomarkers in breast cancer development and progression
| Autor: | Jenny A. Rudnick, Charlotte Kuperwasser |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
CA15-3
Oncology Cancer Research medicine.medical_specialty Stromal cell Breast Neoplasms Biology Breast cancer Immune system Internal medicine Cell Line Tumor medicine Biomarkers Tumor Tumor Microenvironment Humans Breast skin and connective tissue diseases Breast development Tumor microenvironment Cancer General Medicine Fibroblasts medicine.disease Actins Disease Progression Cancer-Associated Fibroblasts Female Stromal Cells |
| Zdroj: | Clinicalexperimental metastasis. 29(7) |
| ISSN: | 1573-7276 |
| Popis: | Breast cancer is a heterogeneous, multi-facto- rial disease of aberrant breast development whose etiology relies upon several microenvironmental changes within the tissue. Within the last decade, it has become widely accepted that tumor cells frequently rely on signals from an activated microenvironment in order to proliferate and survive within a tissue. This activated tissue microenvi- ronment involves the appearance of aSMA ? fibro- blasts (referred to as ''cancer associated fibroblasts''), the recruitment of various immune cells (macrophages, T cells, B cells, T regulatory cells), enhanced collagen I deposition, and epigenetic modifications of stromal cells. These stro- mal changes can predict patient survival and correlate with distinct breast tumor subtypes. Characterizing these stro- mal changes will facilitate their use as clinical biomarkers in breast cancer, and may facilitate their use as potential drug targets for adjuvant breast cancer therapy. |
| Databáze: | OpenAIRE |
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