Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model
| Autor: | Violeta Dancheva, Veneta Shopova, Galya Stavreva, Lyudmil Terziev |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Antioxidant Article Subject Metalloporphyrins medicine.medical_treatment lcsh:Medicine medicine.disease_cause lcsh:Technology Antioxidants General Biochemistry Genetics and Molecular Biology Superoxide dismutase Mice Internal medicine medicine Animals lcsh:Science Lung General Environmental Science chemistry.chemical_classification biology lcsh:T Chemistry Glutathione peroxidase lcsh:R General Medicine Asthma Mice Inbred C57BL Disease Models Animal Oxidative Stress Ovalbumin Endocrinology NPSH Enzyme Catalase Immunology biology.protein Female lcsh:Q Oxidative stress Research Article |
| Zdroj: | The Scientific World Journal, Vol 2012 (2012) The Scientific World Journal |
| ISSN: | 1537-744X |
| DOI: | 10.1100/2012/379360 |
| Popis: | Aim. To investigate the effects of MnTE-2-PyP on some markers of antioxidant defence system in asthma mice model.Material and Methods. The animals were divided into four groups: group 1, controls; group 2, injected with ovalbumin, group 3, treated with MnTE-2-PyP, and group 4, treated with ovalbumin and MnTE-2-PyP. The activities of superoxide dismutase, catalase, glutathione peroxidase and nonprotein sulfhydryl groups content (NPSH) were determined in lung homogenate.Results. The activities of superoxide dismutase and catalase in group 2 decreased significantly as compared to control group. The decrease of the same enzymes in group 4 was lower and significant as compared to group 2. Changes in the glutathione peroxidase activity showed a similar dynamics. The NPSH groups content decreased in group 2. In group 4 this decrease was relatively lower as compared to group 2.Conclusions. The application of MnTE-2-PyP mitigated the effects of oxidative stress in asthma mice model. |
| Databáze: | OpenAIRE |
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