Peripheral CRF-R1/CRF-R2 antagonist, astressin C, induces a long-lasting blockade of acute stress-related visceral pain in male and female rats
| Autor: | Muriel Larauche, Judit Erchegyi, Charleen Miller, Myung Shin Sim, Jean Rivier, Dominic Behan, Yvette Taché |
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| Rok vydání: | 2022 |
| Předmět: |
Diarrhea
Male Hypothalamo-Hypophyseal System Physiology Corticotropin-Releasing Hormone Pituitary-Adrenal System Visceral Pain Biochemistry Receptors Corticotropin-Releasing Hormone Peptide Fragments Rats Rats Sprague-Dawley Cellular and Molecular Neuroscience Endocrinology Hyperalgesia Animals Female Stress Psychological |
| Zdroj: | Peptides. 157 |
| ISSN: | 1873-5169 |
| Popis: | Peptide CRF antagonists injected peripherally alleviate stress-induced visceral hypersensitivity (SIVH) to colorectal distension (CRD) in rodents. Here we further evaluated the dose and time-dependent inhibitory activity of several long-acting peptide CRF receptor antagonists related to astressin on SIVH, focusing on astressin C (AstC), which previously showed high efficacy on stress-related alterations of HPA axis and gut secretomotor functions. Male and female Sprague-Dawley rats pretreated subcutaneously (SC) with AstC were injected intraperitoneally (IP) with CRF 15 min later. The visceromotor responses (VMR) to graded phasic CRD (10, 20, 40 and 60 mmHg) were monitored at basal, 15 min and up to 1-8 days after pretreatment. Two other astressin analogs, hexanoyl-astressin D (Hex-AstD) and [CαMeVal |
| Databáze: | OpenAIRE |
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