Female rats do not develop sucrose-induced insulin resistance
| Autor: | M. J. Pagliassotti, Tracy J. Horton, T. A. Koppenhafer, E. C. Gayles, P. A. Prach |
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| Rok vydání: | 1997 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Physiology medicine.medical_treatment Biology chemistry.chemical_compound Sex Factors Insulin resistance Dietary Sucrose Physiology (medical) Internal medicine medicine Animals Insulin Rats Wistar Triglycerides Pancreatic hormone Triglyceride Glycogen Muscles Body Weight Hypertriglyceridemia Organ Size Carbohydrate medicine.disease Rats Endocrinology Adipose Tissue Liver Basal (medicine) chemistry Female Insulin Resistance Energy Intake |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 272:R1571-R1576 |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.1997.272.5.r1571 |
| Popis: | In male rats, 2 wk of high-sucrose feeding results in insulin resistance and hypertriglyceridemia [Pagliassotti, M.J., P.A. Prach, T.A. Koppenhafer, and D.A. Pan. Am. J. Physiol. 271 (Regulatory Integrative Comp. Physiol. 40): R1319-R1326, 1996]. The present study aimed to determine if female rats also become insulin resistant and hypertriglyceridemic in response to high-sucrose feeding. Female Wistar rats (7 wk old) were fed either a high-sucrose diet (68% energy) (SU) or a high-starch diet (68% energy) (ST) for 3, 5, or 8 wk. In each animal, glucose kinetics were measured using [3-(3)H]glucose under basal and hyperinsulinemic conditions (insulin infusion 4.0 mU.kg-1.min-1). Body weight and basal glucose kinetics were not different between diet groups at 3, 5, or 8 wk. Glucose infusion rate (mg.kg-1.min-1) was not different between groups (3 wk: 17.7 +/- 1.6 ST, 16.6 +/- 0.9 SU; 5 wk: 16.1 +/- 0.9 ST, 15.1 +/- 2.0 SU; 8 wk: 18.3 +/- 1.9 ST, 16.1 +/- 1.5 SU). Clamp rate of glucose appearance (mg.kg-1.min-1) was also not different between diet groups (3 wk: 4.0 +/- 1.6 ST, 3.6 +/- 1.4 SU; 5 wk: 2.6 +/- 1.0 ST, 2.3 +/- 1.14 SU; 8 wk: 5.9 +/- 1.8 ST, 7.7 +/- 1.2 SU). No difference was observed in plasma and tissue triglycerides or tissue glycogen between sucrose- and starch-fed animals. We therefore conclude that female rats, in contrast to males, do not develop sucrose-induced insulin resistance and hypertriglyceridemia. |
| Databáze: | OpenAIRE |
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