Systematic Review on the Role of Lobar Cerebral Microbleeds in Cognition
| Autor: | Lorenzo Cipriano, Dario Saracino, Mariano Oliva, Vito Campana, Gianfranco Puoti, Renata Conforti, Ludovica Fulgione, Elisabetta Signoriello, Simona Bonavita, Cinzia Coppola |
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| Přispěvatelé: | Cipriano, Lorenzo, Saracino, Dario, Oliva, Mariano, Campana, Vito, Puoti, Gianfranco, Conforti, Renata, Fulgione, Ludovica, Signoriello, Elisabetta, Bonavita, Simona, Coppola, Cinzia |
| Rok vydání: | 2022 |
| Předmět: |
General Neuroscience
hippocampal memory General Medicine Magnetic Resonance Imaging Cerebral Amyloid Angiopathy Psychiatry and Mental health Clinical Psychology Cognition executive function Neuropsychological Test Cognitive Dysfunction cerebral microbleed Geriatrics and Gerontology Alzheimer’s disease cognitive impairment Cerebral Hemorrhage Human |
| Zdroj: | Journal of Alzheimer's Disease. 86:1025-1035 |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background: Cerebral microbleeds (CMBs) are small round/oval lesions seen in MRI-specific sequences. They are divided in deep and lobar according to their location. Lobar CMBs (L-CMBs) are commonly associated with amyloid angiopathy. Although CMBs have been considered clinically silent for a long time, a growing body of evidence has shown that they could play a crucial role in cognitive functioning. Objective: The aim of this systematic review was to estimate the role of L-CMBs in cognitive performance. Methods: We selected, from the Cochrane Library, Embase, PubMed, and ScienceDirect databases, clinical studies, published from January 2000 to January 2020 and focused on the association between L-CMBs and cognitive functions. The inclusion criteria were: 1) participants grouped according to presence or absence of CMBs, 2) extensive neuropsychological examination, 3) CMBs differentiation according to topographical distribution, and 4) MRI-based CMB definition ( |
| Databáze: | OpenAIRE |
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