Passive and Iontophoretic Delivery of Three Diclofenac Salts across Various Skin Types
| Autor: | Jia-You Fang, Ren-Jiunn Wang, Yi-Hung Tsai, Yaw-Bin Huang, Pao-Chu Wu |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Diclofenac
Skin Absorption Sodium Mice Nude Pharmaceutical Science chemistry.chemical_element In Vitro Techniques Pharmacology Mice Diclofenac Potassium medicine Animals Transdermal Mice Inbred BALB C Elettaria Iontophoresis Chemistry Anti-Inflammatory Agents Non-Steroidal General Medicine Permeation Lipid Metabolism stomatognathic diseases Paracellular transport Female Drug carrier Hair Follicle medicine.drug |
| Zdroj: | Biological and Pharmaceutical Bulletin. 23:1357-1362 |
| ISSN: | 1347-5215 0918-6158 |
| Popis: | The in vitro permeation of three diclofenac salts--diclofenac sodium (DFS), diclofenac potassium (DFP) and diclofenac diethylammonium (DFD)-across skin by both passive and iontophoretic transport were investigated. Various skin types were used as the barriers to elucidate the mechanism controlling transdermal delivery of diclofenac salts. The importance of the intercellular (paracellular) route for both DFS and DFP in passive permeation was elucidated. The transfollicular route constitutes an important permeation pathway for DFS but not for DFP. The route and mechanism for transdermal iontophoresis of DFD across the skin was somewhat different to that of the other salts. Hair follicles may be a more important pathway for DFD than for DFS and DFP under iontophoresis, while the intercellular lipid pathway showed the opposite result. Combination of iontophoresis and a penetration enhancer, cardamom oil, did not show a synergistic effect on diclofenac salt permeation. The results of this investigation suggest that the transdermal mechanism and the route of diclofenac salt uptake via passive and iontophoretic transport can be affected by their counterions. |
| Databáze: | OpenAIRE |
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