Potential role of galanine in the treatment of type 2 diabetes mellitus
| Autor: | Oksana M. Veselova, Igor Vladimirovich Dobrokhotov, Roman O. Lyubimov |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
RC620-627
Endocrinology Diabetes and Metabolism Glucose uptake medicine.medical_treatment Peroxisome proliferator-activated receptor 030209 endocrinology & metabolism glut4 duodenal hyper-contractility Pharmacology 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance galanine Internal Medicine medicine ppar-g Nutritional diseases. Deficiency diseases Receptor 030304 developmental biology chemistry.chemical_classification 0303 health sciences diabetes biology Insulin Glucose transporter Type 2 Diabetes Mellitus medicine.disease chemistry insulin synthesis biology.protein GLUT4 |
| Zdroj: | Сахарный диабет, Vol 23, Iss 4, Pp 368-373 (2020) |
| ISSN: | 2072-0378 2072-0351 |
| DOI: | 10.14341/dm10195 |
| Popis: | The growing incidence of diabetes mellitus requires the optimizing of existing approaches and searching for new ones to treat this disease. It is necessary to study the features of other regulators that play a significant role in the process of glucose uptake by cells, along with the insulin resistance caused by defects in the molecular mechanisms of insulin action. Galanine, a neuropeptide of 29 (30 in humans) amino acids, is involved in a large number of different vital functions, including regulating energy metabolism in the cell. Galanine interacts with three G protein-coupled receptors, GAL1, GAL2, and GAL3, and transmitting signals through several transduction pathways, including cAMP/PKA inhibition (GAL1, GAL3) and phospholipase C (GAL2) stimulation. Agonists and antagonists of galanine receptor subtype GalR1-3 can be used as intended therapeutic targets to treat various human diseases. We accumulated more data that prove the importance of the galanine peptide regulator in the etiology of impaired glucose uptake by insulin-dependent tissues. The review considers such effects of galanine, as inhibition of insulin synthesis, activation of expression and translocation to the plasma cell membrane of the glucose transporter GLUT4, increase of PPAR-g level, and decrease in duodenal hyper-contractility. These data confirm the importance of research to find an effective antidiabetic drug among the synthesized analogs of galanine. |
| Databáze: | OpenAIRE |
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