Effects of citrate acid concentrate on hemodialysis adequacy, reuse, and quality of life: A prospective randomized crossover trial
| Autor: | Aswani Srinivas Mareddy, Sindhura Lakshmi Koulmane Laxminarayana, Shankar Prasad, Srinivas Shenoy, Rajeevalochana Parthasarathy, Sindhu Kaza, Uday Venkat Mateti, Ravindra Prabhu Attur, Vasudev Guddattu, Srinivas Kosuru, D. Rangaswamy, Shankar Prasad Nagaraju, Karan Saraf |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Nephrology
medicine.medical_specialty medicine.medical_treatment Bicarbonate Urea reduction ratio 030232 urology & nephrology Urology 030204 cardiovascular system & hematology lcsh:RC870-923 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Quality of life Internal medicine Medicine Acidosis Dialysis adequacy business.industry dialysis adequacy dialyzer reuse lcsh:Diseases of the genitourinary system. Urology Crossover study chemistry quality of life Original Article Hemodialysis medicine.symptom business Citrate dialysate |
| Zdroj: | Indian Journal of Nephrology, Vol 28, Iss 4, Pp 287-290 (2018) Indian Journal of Nephrology |
| ISSN: | 1998-3662 0971-4065 |
| Popis: | We conducted a randomized crossover trial to identify whether the use of citrate dialysate (CD) for bicarbonate hemodialysis is beneficial compared to regular acetate dialysate (AD) in terms of adequacy, reuse, and quality of life. Thirty-two stable end-stage renal disease patients on twice-weekly maintenance hemodialysis were randomly assigned to CD or AD fluid in a single-blinded randomized prospective crossover trial of 1-year duration. The primary outcomes studied were the impact of CD in comparison with AD on hemodialysis adequacy, reuse of dialyzer, and quality of life. Secondary outcomes studied were the effect on intradialytic hypotension, acidosis correction, and episodes of symptomatic hypocalcemia. A total number of 28 patients underwent a total of 1456 sessions of hemodialysis with CD over 6 months and 1456 sessions with AD over 6 months. There was a significant increase in dialyzer reuse with the use of CD (P = 0.02). There was no difference in dialyzer adequacy as measured by Single pool Kt/V (spKt/V) (P = 0.840) and urea reduction ratio (%) (P = 0.90). Quality of life did not differ between the two groups. No statistically significant difference was observed in predialysis arterial pH (P = 0.23) serum bicarbonate (0.17) and calcium change (P = 0.16). CD is safe and equally effective as compared to AD. It significantly improves the reuse of dialyzer but it does not offer any added advantage in terms of improvement in hemodialysis adequacy and quality of care. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|